HIV Pharm - INSTIs

Question 1

INSTI

Answer 1

Integrase Strand Transfer Inhibitors

Question 2

General MOA for INSTIs?

Answer 2

(-) viral and host DNA bonds and transfer

- integrase

Question 3

General MOA for INSTIs?

Answer 3

(-) viral and host DNA bonds and transfer

- integrase

Question 4

INSTIs are the primary +1 drug for?

Answer 4

Naive patients

Question 5

INSTIs are the primary +1 drug for?

Answer 5

Naive patients

Question 6

Raltegravir is NOT available in?

Answer 6

Single tablets

Question 7

Raltegravir resistance can develop due to mutations in?

Answer 7

Integrase

Question 8

Adverse side effects of Raltegravir?

Answer 8

Immune reconstitution syndrome

Myopathy

Question 9

Dolutegravir has a ___ genetic barrier to resistance

Answer 9

HIGH

Question 10

What metabolizes Dolutegravir?

Answer 10

UGR1A1 glucuronidation

Question 11

Adverse side effect of Dolutegravir?

Answer 11

Significant weight gain

Question 12

What metabolizes Elvitegravir?

Answer 12

CYP3A4

Question 13

Elvitegravir will need /r or /c. Why?

Answer 13

It is metabolized by CYP3A4

Question 14

Bictegravir has a ___ genetic barrier to resistance

Answer 14

HIGH

Question 15

What INSTI is best absorbed?

Answer 15

Bictegravir

Question 16

What metabolizes Bictegravir?

Answer 16

UGT1A1 and CYP3A4

Question 17

What INSTI is best absorbed?

Answer 17

Bictegravir

Question 18

Adverse side effect of Bictegravir?

Answer 18

Weight gain

Question 19

What INSTIs can cause weight gain?

Answer 19

Bictegravir

Dolutegravir

Question 20

What INSTIs have HIGH genetic barriers to resistance?

Answer 20

Bictegravir

Dolutegravir

Question 21

What other agent (NRTI) can be added to Dolutegravir to treat naive patients?

Answer 21

Iamivudine

Question 22

What other agent (NRTI) can be added to Dolutegravir to treat naive patients?

Answer 22

Iamivudine