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SBL > Cancer Pharmacology - Alkylating agents > Flashcards

Cancer Pharmacology - Alkylating agents Flashcards

1
Q

Alkylating agents - cell cycle specific?

A

NO

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2
Q

What is the MOA for all of the Alkylating agents?

A

Form covalent linkages with DNA that causes strand cross-linking and miscoding
= Tumor cannot unwind DNA for replication and mRNA production

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3
Q

What is the MOA for all of the Alkylating agents?

A

Form covalent linkages with DNA that causes strand cross-linking and miscoding
= Tumor cannot unwind DNA for replication and mRNA production

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4
Q

What are 2 Nitrogen Mustards?

A

Cyclophosphamide

Ifosamide

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5
Q

Cyclophosphamide causes a buildup of?

A

Acrolein

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6
Q

Cyclophosphamide causes a buildup of Acrolein. What does this cause?

A

Hemorrhagic Cystitis

bladder inflammation

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7
Q

What can be used for prophylaxis of Hemorrhagic Cystitis from Cyclophosphamide?

A

Mesna

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8
Q

Adverse side effect of Cyclophosphamide

A

Hemorrhagic Cystitis

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9
Q

What can be used for prophylaxis of Hemorrhagic Cystitis from Cyclophosphamide?

A

Mesna

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10
Q

What is 1 Alkyl Sulfonate?

A

Busulfan

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11
Q

What is 1 Alkyl Sulfonate?

A

Busulfan

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12
Q

What 3 adverse effects can Busulfan cause?

A

Hyperpigmentation, pulmonary fibrosis and adrenal insufficiency

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13
Q

What 3 adverse effects can Busulfan cause?

A

Hyperpigmentation, pulmonary fibrosis and adrenal insufficiency

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14
Q

What is 1 Platinum Coordination Complex?

A

Cisplatin

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15
Q

What is 1 Platinum Coordination Complex?

A

Cisplatin

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16
Q

What 2 adverse effects can Cisplatin cause?

A

Renal tubular damage

Ototoxicity

17
Q

What 2 adverse effects can Cisplatin cause?

A

Renal tubular damage

Ototoxicity

18
Q

What can prevent that Renal tubular damage from Cisplatin?

A

Hydration

19
Q

What are the symptoms of ototoxicity caused by Cisplatin?

A

Tinnitus and high-frequency hearing loss

20
Q

Cisplatin can also cause nausea and vomiting. What can prevent this?

A

Serotonin antagonist

SBL (48 decks)

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