Cellular Skin Migrants and Acute Inflammatory Disorders

Question 1

Mycosis Fungoides

Answer 1

CD4+ T cell lymphoma

Question 2

If Mycosis Fungoides progresses to a more severe tumor, what are the stages of what you will see on the skin?

Answer 2

Scaly red and brown:

1. Patch
2. Plaque
3. Nodule

Question 3

Sezary Syndrome

Answer 3

T cell lymphoma with erythroderma and scaling of entire body

Question 4

Sezary cells have what type of nucleus?

Answer 4

Cerebriform (folded)

Question 5

Sezary cells can create _____ in the superficial dermis

Answer 5

Band-like aggregates

Question 6

Sezary cells can create Pautrier Microabscesses in the epidermis. What are those?

Answer 6

Clusters of cells in the epidermis

Question 7

Mastocytosis involves what being released from mast cells?

Answer 7

Histamine

Heparin

Question 8

When the skin is rubbed with Mastocytosis, what will result?

Answer 8

Dermal edema

Question 9

Mastocytosis can cause ___ in younger people due to the histamine being released

Answer 9

Osteoporosis

Question 10

Mastocytosis often affects children. What is that called?

Answer 10

Urticaria pigmentosa

Question 11

Urticaria pigmentosa affects?

Answer 11

Children

Question 12

Urticaria pigmentosa symptoms?

Answer 12

• Children

= Multiple, round lesions that are red and nonscaling

Question 13

Mastocytosis involves point mutations in what that causes the mast cell growth and survival?

Answer 13

KIT - causes mast cell growth and survival

Question 14

Impaired epidermal maturation with excessive keratin buildup?

Answer 14

Ichthyosis

Question 15

Ichthyosis

Answer 15

Impaired epidermal maturation with excessive keratin buildup

- fish like scales

Question 16

What will be present with Ichthyosis?

Answer 16

FISH-like scales

Question 17

Fish like scales are present with what abnormal epidermal maturation?

Answer 17

Ichthyosis

Question 18

What cell infiltrates characterize Acute Inflammatory disorders?

Answer 18

Lymphocytes and Macrophages

Question 19

What cell infiltrates characterize Acute Inflammatory disorders?

Answer 19

Lymphocytes and Macrophages

Question 20

Urticaria

Answer 20

Hives

Question 21

Urticaria involves antigen - induced?

Answer 21

Release of vasoactive mediators from mast cells

Question 22

Antigen-induced release of vasoactive mediators from mast cells is seen with?

Answer 22

Urticaria

Question 23

What may cause Acute Eczematous Dermatitis?

Answer 23

External application of antigen or ingestion of food/drug

Question 24

What type of hypersensitivity reaction is Acute Eczematous Dermatitis?

Answer 24

Type 4

- T cell mediated inflammatory reaction

Question 25

What is an example of an antigen that can cause Acute Eczematous Dermatitis?

Answer 25

Poison Ivy

Question 26

Erythema Multiforme involves keratinocyte injury by?

Answer 26

CD8+ T cells

Question 27

CD8+ T cells injury _____ with Erythema Multiforme

Answer 27

Keratinocytes