Pre/Malignant Tumors and Tumors of Dermis

Question 1

Where does Actinic Keratosis develop?

Answer 1

Sun - damaged skin

Question 2

Actinic Keratosis can progress to?

Answer 2

Squamous cell carcinoma

Question 3

What does Actinic Keratosis look/feel like?

Answer 3

Sandpaper feeling, brown-pink with a cutaneous horn

Question 4

Actinic Chelitis is Actinic Keratosis but where?

Answer 4

Lips

Question 5

2nd most common cutaneous malignancy?

Answer 5

Squamous cell carcinoma

Question 6

What causes squamous cell carcinoma?

Answer 6

DNA damage induced by UV light

Question 7

What things can increase risk for developing Squamous cell carcinoma?

Answer 7

• Immunosuppresion (HPV 5 and 8)

- Chronic ulcers, tobacco and betel nut chewing

Question 8

Is metastasis common for squamous cell carcinomas?

Answer 8

No <5%

Question 9

3 signaling mutations are present with squamous cell carcinoma. What are they?

Answer 9

TP53
RAS
Decreased NOTCH signaling

Question 10

3 signaling mutations are present with squamous cell carcinoma. What are they?

Answer 10

TP53
RAS
Decreased NOTCH signaling

Question 11

Xeroderma Pigmentosum has mutations in?

Answer 11

Nucleotide excision repair

Question 12

Xeroderma Pigmentosum is at an increased risk of developing what malignancy?

Answer 12

Squamous cell carcinoma

Question 13

What is the most common cutaneous malignancy?

Answer 13

Basal cell carcinoma

Question 14

Is metastasis common for basal cell carcinoma?

Answer 14

No - slow growing

Question 15

With Basal cell carcinoma, there is increased ____ signaling due to the ____ gene

Answer 15

Increased Hedgehog signaling

PTCH gene

Question 16

Increased Hedgehog signaling with the PTCH gene is seen with?

Answer 16

Basal cell carcinoma

Question 17

Nevoid Basal Cell Carcinoma Syndrome (Gorlin syndrome)

Answer 17

Multiple Basal cell carcinomas before 20 years old!

Question 18

Nevoid Basal Cell Carcinoma syndrome (Gorlin syndrome)

Answer 18

Multiple Basal cell carcinomas before 20 years old!

Question 19

What physical things are seen with Basal Cell Carcinoma?

Answer 19

Pearly papules

Telangiectasias and rodent ulcers

Question 20

Pearly papules, telangiectasias and rodent ulcers are seen with?

Answer 20

Basal cell carcinoma

Question 21

Cells are arranged radially (Peripheral Palisading) with what malignancy?

Answer 21

Basal cell carcinoma

Question 22

Benign Fibrous Histiocytoma is a tumor of the dermis. It has a ____ overlying epidermis

Answer 22

THICK

Question 23

Benign Fibrous Histiocytoma is common where?

Answer 23

On the legs of women - history of trauma

Question 24

What sign will be (+) with Benign Fibrous Histiocytoma?

Answer 24

Dimple sign = lateral pressure on skin produces a depression

Question 25

Lateral pressure on skin produces a depression

Answer 25

Dimple sign

- Seen with Benign Fibrous Histiocytoma

Question 26

Benign Fibrous Histiocytoma has ____ shaped cells

Answer 26

Spindle shaped cells

Question 27

Dermatofibrosarcoma Protuberans has a _____ overlying epidermis

Answer 27

THIN

Question 28

What genes promote tumor cell growth with Dermatofibrosarcoma Protuberans?

Answer 28

COL1A1 and PDGFB

Question 29

How are fibroblasts arranged with Dermatofibrosarcoma Protuberans?

Answer 29

Like a pinwheel (storiform)

Question 30

Dermatofibrosarcoma Protuberans is a tumor of the dermis. What pattern does it entail if it extends into subQ fat?

Answer 30

Honeycomb pattern

Question 31

Pinwheel (storiform) arrangement of fibroblasts is seen with what dermal tumor?

Answer 31

Dermatofibrosarcoma Protuberans