Pre/Malignant Tumors and Tumors of Dermis Flashcards
Where does Actinic Keratosis develop?
Sun - damaged skin
Actinic Keratosis can progress to?
Squamous cell carcinoma
What does Actinic Keratosis look/feel like?
Sandpaper feeling, brown-pink with a cutaneous horn
Actinic Chelitis is Actinic Keratosis but where?
Lips
2nd most common cutaneous malignancy?
Squamous cell carcinoma
What causes squamous cell carcinoma?
DNA damage induced by UV light
What things can increase risk for developing Squamous cell carcinoma?
- Immunosuppresion (HPV 5 and 8)
- Chronic ulcers, tobacco and betel nut chewing
Is metastasis common for squamous cell carcinomas?
No <5%
3 signaling mutations are present with squamous cell carcinoma. What are they?
TP53
RAS
Decreased NOTCH signaling
3 signaling mutations are present with squamous cell carcinoma. What are they?
TP53
RAS
Decreased NOTCH signaling
Xeroderma Pigmentosum has mutations in?
Nucleotide excision repair
Xeroderma Pigmentosum is at an increased risk of developing what malignancy?
Squamous cell carcinoma
What is the most common cutaneous malignancy?
Basal cell carcinoma
Is metastasis common for basal cell carcinoma?
No - slow growing
With Basal cell carcinoma, there is increased ____ signaling due to the ____ gene
Increased Hedgehog signaling
PTCH gene
Increased Hedgehog signaling with the PTCH gene is seen with?
Basal cell carcinoma
Nevoid Basal Cell Carcinoma Syndrome (Gorlin syndrome)
Multiple Basal cell carcinomas before 20 years old!
Nevoid Basal Cell Carcinoma syndrome (Gorlin syndrome)
Multiple Basal cell carcinomas before 20 years old!
What physical things are seen with Basal Cell Carcinoma?
Pearly papules
Telangiectasias and rodent ulcers
Pearly papules, telangiectasias and rodent ulcers are seen with?
Basal cell carcinoma
Cells are arranged radially (Peripheral Palisading) with what malignancy?
Basal cell carcinoma
Benign Fibrous Histiocytoma is a tumor of the dermis. It has a ____ overlying epidermis
THICK
Benign Fibrous Histiocytoma is common where?
On the legs of women - history of trauma
What sign will be (+) with Benign Fibrous Histiocytoma?
Dimple sign = lateral pressure on skin produces a depression
Lateral pressure on skin produces a depression
Dimple sign
- Seen with Benign Fibrous Histiocytoma
Benign Fibrous Histiocytoma has ____ shaped cells
Spindle shaped cells
Dermatofibrosarcoma Protuberans has a _____ overlying epidermis
THIN
What genes promote tumor cell growth with Dermatofibrosarcoma Protuberans?
COL1A1 and PDGFB
How are fibroblasts arranged with Dermatofibrosarcoma Protuberans?
Like a pinwheel (storiform)
Dermatofibrosarcoma Protuberans is a tumor of the dermis. What pattern does it entail if it extends into subQ fat?
Honeycomb pattern
Pinwheel (storiform) arrangement of fibroblasts is seen with what dermal tumor?
Dermatofibrosarcoma Protuberans
