Psoriasis and Actinic Keratoses

Question 1

What are some topical therapies for Psoriasis?

Answer 1

Tar, salt water bath, emollients, corticosteroids, vitamin D analogs

Question 2

Tar, salt water bath, vitamin D analogs and others can treat?

Answer 2

Psoriasis

Question 3

What are 2 UV light therapies to treat Psoriasis?

Answer 3

UVB

PUVA

Question 4

UVB light therapy to treat Psoriasis can also choose to add?

Answer 4

Tar

Question 5

PUVA light therapy to treat Psoriasis uses what radiation?

Answer 5

UVA radiation

Question 6

What do you have to ingest before treatment with PUVA?

Answer 6

Psoralen

Question 7

Psoralen is ingested before?

Answer 7

Treatment with PUVA (UVA radiation) to treat psoriasis

Question 8

What are 3 systemic therapies to treat Psoriasis?

Answer 8

Apremilast
Ustekinumab
Secukinumab

Question 9

What are 3 systemic therapies to treat Psoriasis?

Answer 9

Apremilast
Ustekinumab
Secukinumab

Question 10

MOA for Apremilast

Answer 10

Inhibits PDE4 which causes an INCREASE in cAMP

Question 11

What conditions can Apremilast treat?

Answer 11

Moderate/severe plaque psoriasis and psoriatic arthritis

Question 12

Adverse effects of Apremilast?

Answer 12

Short term diarrhea, depression, headache

Question 13

MOA for Ustekinumab

Answer 13

Reduces IL-12 and IL-23

Question 14

What conditions can Ustekinumab treat?

Answer 14

Plaque psoriasis, psoriatic arthritis and crohn’s disease

Question 15

Adverse effects of Ustekinumab?

Answer 15

Increased risk for infections

Question 16

MOA for Secukinumab

Answer 16

Reduces IL-17A

Question 17

What conditions can Secukinumab treat?

Answer 17

Plaque psoriasis, psoriatic arthritis, ankylosing spondylitis

Question 18

Adverse effects of Secukinumab?

Answer 18

Increased risk for infections

Question 19

This drug to treat Psoriasis can cause short term diarrhea

Answer 19

Apremilast

Question 20

These drugs to treat Psoriasis can cause an increased risk for infections

Answer 20

Ustekinumab

Secukinumab

Question 21

This drug to treat Psoriasis reduces IL-17A

Answer 21

Secukinumab

Question 22

This drug to treat Psoriasis reduces IL-12 and IL-23

Answer 22

Ustekinumab

Question 23

What is Actinic Keratosis?

Answer 23

Neoplasms that develop on sun-damaged skin

Question 24

What are neoplasms that develop on sun-damaged skin?

Answer 24

Actinic Keratosis

Question 25

What are 3 drugs to treat Actinic Keratosis?

Answer 25

Topical 5-Fluoruracil
Imiquimod
Ingenol Mebutate

Question 26

MOA for Topical 5-Fluorouracil?

Answer 26

• Treats Actinic Keratosis

= Inhibits thymidylate synthase = NO DNA synthesis

Question 27

Topical 5-Fluoruracil inhibits thymidylate synthase what also inhibits DNA synthesis. What does this result in?

Answer 27

Prevents cell proliferation and causes neoplastic cell death

Question 28

End result of using Topical 5-Fluorouracil?

Answer 28

Inflammation and destruction of lesions with Actinic Keratosis

Question 29

What drug to treat Actinic Keratosis can also treat genital warts?

Answer 29

Imiquimod

Question 30

MOA for Imiquimod?

Answer 30

Inflammatory cell infiltration

Question 31

MOA for Ingenol Mebutate?

Answer 31

1. Cell necrosis

2. Neutrophil mediated antibody dependent cellular cytotoxicity

Question 32

This drug for Actinic Keratosis causes inflammatory cell infiltration

Answer 32

Imiquimod

Question 33

this drug for Actinic Keratosis can also treat genital warts

Answer 33

Imiquimod

Question 34

This drug for Actinic Keratosis first causes cell necrosis and then causes neutrophil mediated antibody dependent cellular cytotoxicity

Answer 34

Ingenol Mebutate

Question 35

This drug for Actinic Keratosis prevents cell proliferation and causes cell death

Answer 35

Topical 5-Fluorouracil