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SBL > Psoriasis and Actinic Keratoses > Flashcards

Psoriasis and Actinic Keratoses Flashcards

1
Q

What are some topical therapies for Psoriasis?

A

Tar, salt water bath, emollients, corticosteroids, vitamin D analogs

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2
Q

Tar, salt water bath, vitamin D analogs and others can treat?

A

Psoriasis

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3
Q

What are 2 UV light therapies to treat Psoriasis?

A

UVB

PUVA

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4
Q

UVB light therapy to treat Psoriasis can also choose to add?

A

Tar

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5
Q

PUVA light therapy to treat Psoriasis uses what radiation?

A

UVA radiation

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6
Q

What do you have to ingest before treatment with PUVA?

A

Psoralen

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7
Q

Psoralen is ingested before?

A

Treatment with PUVA (UVA radiation) to treat psoriasis

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8
Q

What are 3 systemic therapies to treat Psoriasis?

A

Apremilast
Ustekinumab
Secukinumab

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9
Q

What are 3 systemic therapies to treat Psoriasis?

A

Apremilast
Ustekinumab
Secukinumab

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10
Q

MOA for Apremilast

A

Inhibits PDE4 which causes an INCREASE in cAMP

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11
Q

What conditions can Apremilast treat?

A

Moderate/severe plaque psoriasis and psoriatic arthritis

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12
Q

Adverse effects of Apremilast?

A

Short term diarrhea, depression, headache

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13
Q

MOA for Ustekinumab

A

Reduces IL-12 and IL-23

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14
Q

What conditions can Ustekinumab treat?

A

Plaque psoriasis, psoriatic arthritis and crohn’s disease

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15
Q

Adverse effects of Ustekinumab?

A

Increased risk for infections

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16
Q

MOA for Secukinumab

A

Reduces IL-17A

17
Q

What conditions can Secukinumab treat?

A

Plaque psoriasis, psoriatic arthritis, ankylosing spondylitis

18
Q

Adverse effects of Secukinumab?

A

Increased risk for infections

19
Q

This drug to treat Psoriasis can cause short term diarrhea

A

Apremilast

20
Q

These drugs to treat Psoriasis can cause an increased risk for infections

A

Ustekinumab

Secukinumab

21
Q

This drug to treat Psoriasis reduces IL-17A

A

Secukinumab

22
Q

This drug to treat Psoriasis reduces IL-12 and IL-23

A

Ustekinumab

23
Q

What is Actinic Keratosis?

A

Neoplasms that develop on sun-damaged skin

24
Q

What are neoplasms that develop on sun-damaged skin?

A

Actinic Keratosis

25
Q

What are 3 drugs to treat Actinic Keratosis?

A

Topical 5-Fluoruracil
Imiquimod
Ingenol Mebutate

26
Q

MOA for Topical 5-Fluorouracil?

A
  • Treats Actinic Keratosis

= Inhibits thymidylate synthase = NO DNA synthesis

27
Q

Topical 5-Fluoruracil inhibits thymidylate synthase what also inhibits DNA synthesis. What does this result in?

A

Prevents cell proliferation and causes neoplastic cell death

28
Q

End result of using Topical 5-Fluorouracil?

A

Inflammation and destruction of lesions with Actinic Keratosis

29
Q

What drug to treat Actinic Keratosis can also treat genital warts?

A

Imiquimod

30
Q

MOA for Imiquimod?

A

Inflammatory cell infiltration

31
Q

MOA for Ingenol Mebutate?

A
  1. Cell necrosis

2. Neutrophil mediated antibody dependent cellular cytotoxicity

32
Q

This drug for Actinic Keratosis causes inflammatory cell infiltration

A

Imiquimod

33
Q

this drug for Actinic Keratosis can also treat genital warts

A

Imiquimod

34
Q

This drug for Actinic Keratosis first causes cell necrosis and then causes neutrophil mediated antibody dependent cellular cytotoxicity

A

Ingenol Mebutate

35
Q

This drug for Actinic Keratosis prevents cell proliferation and causes cell death

A

Topical 5-Fluorouracil

SBL (48 decks)

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