Chronic Inflammatory Disorders and Blistering Diseases

Question 1

What does Psoriasis look like?

Answer 1

Salmon plaque with a silver scale

Question 2

What nail presentations may be common with Psoriasis?

Answer 2

Yellow-brown nails

Oncolysis - separation of nail and nail bed

Question 3

Psoriasis is a type of ____ disease

Answer 3

Autoimmune

Question 4

What is the Koebner phenomenon and what is it seen with?

Answer 4

• Seen with psoriasis and lichen planus

= Local trauma induces psoriasis lesions

Question 5

What is the Auspitz sign and what is it seen with?

Answer 5

• Seen with psoriasis

= bleeding when scale lifted from psoriasis plaque

Question 6

Lichen Planus 6 P’s

Answer 6

Purple
Pruritic
Polygonal
Planar
Papule
Plaque

Question 7

Lichen Planus 6 P’s

Answer 7

Purple
Pruritic
Polygonal
Planar
Papule
Plaque

Question 8

What can be seen on the papules with Lichen Planus?

Answer 8

Wickham striae = white dots

Question 9

What can be seen on the papules with Lichen Planus?

Answer 9

Wickham striae = white dots

Question 10

Lichen Planus may cause what malignancy?

Answer 10

Squamous cell carcinoma

Question 11

Lichen planus resolves spontaneously and leaves behind?

Answer 11

Hyperpigmentations

Question 12

What are the 2 chronic inflammatory disorders?

Answer 12

Psoriasis

Lichen Planus

Question 13

Pemphigus involves what autoantibodies?

Answer 13

IgG

Question 14

Pemphigus involves what autoantibodies?

Answer 14

IgG

Question 15

What do IgG antibodies do with Pemphigus?

Answer 15

Disrupt intracellular adhesion = blisters

Question 16

Pemphigus shows what type of pattern of IgG deposits?

Answer 16

Net-like

Question 17

Pemphigus vulgaris vesicles rupture - easy or hard?

Answer 17

Easily rupture

Question 18

Bullous Pemphigoid affects what patient population?

Answer 18

Elderly

Question 19

Where do antibodies deposit with Bullous Pemphigoid?

Answer 19

Dermoepidermal junction

Question 20

Where do antibodies deposit with Bullous Pemphigoid?

Answer 20

Dermoepidermal junction

Question 21

Bullous Pemphigoid vesicles rupture - easy or hard?

Answer 21

Hardly ever rupture

Question 22

Bullous Pemphigoid vesicles are commonly on flexor surfaces and on what level of the skin?

Answer 22

Subepidermal

Question 23

Dermatitis Herpetiformis

Answer 23

Grouped vesicles, bilateral and symmetric

Question 24

Dermatitis Herpetiformis

Answer 24

Grouped vesicles, bilateral and symmetric

Question 25

Dermatitis Herpetiformis often affects extensor surfaces. What disease is it associated with and what antibodies develop?

Answer 25

Celiac disease

- IgA antibodies to gluten

Question 26

Dermatitis Herpetiformis is associated with Celiac disease and develops IgA antibodies. How do you get a blister from that?

Answer 26

IgA antibodies to gluten cross react with reticulin

= subepidermal blister

Question 27

Dermatitis Herpetiformis are commonly on extensor surfaces and on what level of the skin?

Answer 27

Subepidermal

Question 28

What are the 2 types of NON-inflammatory blisters?

Answer 28

Epidermolysis Bullosa

Porphyria

Question 29

What are the 2 types of NON-inflammatory blisters?

Answer 29

Epidermolysis Bullosa

Porphyria

Question 30

Where are blisters located with Epidermolysis Bullosa?

Answer 30

Sites of pressure, rubbing, trauma

Question 31

Epidermolysis Bullosa involves inherited defects in?

Answer 31

Structural proteins

Question 32

Porphyria involves issues with?

Answer 32

Porphyrin metabolism

Question 33

Symptoms of Porphyria?

Answer 33

Vesicles with scarring made worse with sunlight

Question 34

Symptoms of Porphyria?

Answer 34

Vesicle with scarring made worse with sunlight