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SBL > Skin cancer and Alopecia Treatments > Flashcards

Skin cancer and Alopecia Treatments Flashcards

1
Q

What 2 drugs can treat Basal/Squamous cell carcinomas?

A

Vismodegib

Sonidegib

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2
Q

What 2 drugs can treat Basal/Squamous cell carcinomas?

A

Vismodegib

Sonidegib

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3
Q

MOA for Vismodegib and Sonidegib?

A

Inhibits hedgehog pathway

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4
Q

These drugs inhibit the hedgehog pathway to treat basal/squamous cell carcinomas

A

Vesmodegib

Sonidegib

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5
Q

What 2 drugs can treat Melanoma?

A

Dacarbazine

Vemurafenib

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6
Q

What 2 drugs can treat Melanoma?

A

Dacarbazine

Vemurafenib

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7
Q

Conventional chemo treatment for Melanoma?

A

Dacarbazine

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8
Q

Dacarbazine treats?

A

Melanoma

- conventional chemo treatment

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9
Q

MOA for Vemurafenib

A

Inhibits MAP kinase pathway = apoptosis

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10
Q

What drug for Melanoma inhibits the MAP kinase pathway to cause apoptosis?

A

Vemurafenib

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11
Q

First line of treatment for Alopecia (male and female)?

A

Minoxidil

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12
Q

MOA for Minoxidil

A

Vasodilates due to K+ channel opening

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13
Q

What does Minoxidil cause?

A

Increased growth phase
Reduced rest phase
Enlargement of follicles

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14
Q

First line of treatment for Alopecia (male and female)?

A

Minoxidil

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15
Q

This drug causes vasodilation due to K+ channel opening

A

Minoxidil

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16
Q

What other drugs are available to treat Alopecia besides Minoxidil?

A

Finasteride
Spironolactone
Flutamide

17
Q

MOA for Finasteride

A

Inhibits Dihydroxytestosterone (DHT)

18
Q

Adverse effects of Finasteride

A

Sexual dysfunction – due to (-) DHT

19
Q

What is an androgen partial agonist to treat female hair loss?

A

Spironolactone

20
Q

What drug to treat Alopecia inhibits DHT?

A

Finasteride

21
Q

What is Alopecia Areata?

A

Immune mediated inflammatory disorder that causes non-scarring hair loss from many locations

22
Q

What is Alopecia Areata?

A

Immune mediated inflammatory disorder that causes non-scarring hair loss from many locations

23
Q

What is the topical treatment for Alopecia Areata?

A

Diphenylcyclopropenone (DPCP)

24
Q

What is the topical treatment for Alopecia Areata?

A

Diphenylcyclopropenone (DPCP)

25
Q

What is an adverse effect of using Diphenylcyclopropenone (DPCP) to treat Alopecia Areata?

A

Causes contact dermatitis = CAUSES HAIR GROWTH

26
Q

How does Diphenylcyclopropenone (DPCP) cause hair growth?

A

Through its adverse effect = contact dermatitis

27
Q

DPCP to treat Alopecia Areata causes contact dermatitis which then causes?

A

HAIR GROWTH

SBL (48 decks)

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