Cancer Pharmacology Flashcards
Aberrations in checkpoint regulation of the cell cycle will cause?
Uncontrolled cell proliferation
Activation of oncogenes cause what to the cell cycle checkpoints?
Override G1 arrest
Loss of tumor suppressor genes cause what to the cell cycle checkpoints?
Override G2 arrest
What is the Growth Fraction?
Ratio of proliferating cells to G0 cells
What is a major determinant of responsiveness to chemo?
Growth Fraction
Antineoplastic agents are more effective on cells with a ____ Growth Fraction
HIGH
Antineoplastic agents are more effective on cells with a ____ Growth Fraction
HIGH
Since Antineoplastic agents work best on high growth fraction cells, what normal tissues will be affected?
Hair follicles, sperm, bone marrow, etc.
Why are solid tumors harder to treat?
Their growth fraction DECREASES over time
– higher growth fractions are easier to treat
What is the log cell kill hypothesis?
Antineoplastic agents kill a FRACTION of cells per dose
_______ allows for recovery of normal tissues
Intermittent therapy
What are Pharmacologic Sanctuaries?
Regions where tumor cells are less susceptible to antineoplastic agents
ex. CNS
Is Combination drug therapy better than a single agent?
Yes
What can be used with radiation/surgery to treat high grade malignant glioma patients?
Implantable wafer coated with carmustine (a nitrosurea)
Where is P-glycoprotein normally expressed?
Tissues with barrier functions
- blood/brain, placenta, kidney, liver, etc.
