HIV Pharm - NNRTIs and Entry blockers

Question 1

NNRTIs

Answer 1

Non-Nucleoside Reverse Transcriptase inhibitors

Question 2

NNRTIs inhibit?

Answer 2

Reverse transcriptase

- Viral RNA going to DNA

Question 3

What strand of HIV are NNRTIs ONLY active against?

Answer 3

HIV-1

Question 4

What strand of HIV are NNRTIs ONLY active against?

Answer 4

HIV-1

Question 5

What can cause resistance to NNRTIs?

Answer 5

Single aa substitution

Question 6

Adverse side effects of Efavirenz?

Answer 6

CNS toxicity and Psychiatric side effects

Question 7

Adverse side effects of Efavirenz?

Answer 7

CNS toxicity and Psychiatric side effects

Question 8

What is unique about Etravirine?

Answer 8

It still works after mutations that disrupt activity of other NNRTIs

Question 9

What drug can still work after mutations have disrupted the activity of other NNRTIs?

Answer 9

Etravirine

Question 10

Rilpivirine needs to be taken with?

Answer 10

A meal

Question 11

Adverse side effects of Rilpivirine are common in?

Answer 11

Children and Adolescents

- Depression and rash

Question 12

Adverse side effects of Rilpivirine are common in?

Answer 12

Children and Adolescents

- Depression, rash

Question 13

What is a new NNRTI that has novel resistance mutations?

Answer 13

Doravirine

Question 14

What NNRTI is better and newer than all other NNRTIs?

Answer 14

Doravirine

Question 15

Doravirine is?

Answer 15

Better than other NNRTIs

Question 16

Does Doravirine have any significant drug interactions?

Answer 16

NO

Question 17

What drug blocks HIV entry by inhibiting fusion to the host cell?

Answer 17

Enfuvirtide

Question 18

What drug blocks HIV entry by inhibiting fusion to the host cell?

Answer 18

Enfuvirtide

Question 19

Why is Enfuvirtide not used often?

Answer 19

Must be administered parenterally

Question 20

What drug blocks HIV entry by blocking CCR5?

Answer 20

Maraviroc

Question 21

What drug blocks HIV entry by blocking CCR5?

Answer 21

Maraviroc

Question 22

Maraviroc blocks binding of what ligands?

Answer 22

CCR5 and GP120

Question 23

Why is Maraviroc not used often?

Answer 23

Not active against CXCR4 viruses