Cancer Pharmacology - Natural Products cont. Flashcards
What are 2 Antibiotics?
Doxorubicin
Bleomycin
What are 2 Antibiotics?
Doxorubicin
Bleomycin
MOA for Doxorubicin? (multiple)
(-) Topoisomerase 2
(-) DNA synthesis
INCREASES free radicals
MOA for Doxorubicin? (multiple)
(-) Topoisomerase 2
(-) DNA synthesis
INCREASES free radicals
Adverse side effects of Doxorubicin?
Cardiotoxicity, red urine, etc.
What antibiotic can cause Cardiotoxicity?
Doxorubicin
MOA for Bleomycin
DNA strand breaks
Adverse side effects of Bleomycin?
Pulmonary toxicity - pneumonitis, cough, dyspnea, dry inspiratory crackles
Adverse side effects of Bleomycin?
Pulmonary toxicity - pneumonitis, cough, dyspnea, dry inspiratory crackles
What antibiotic can cause dry inspiratory crackles in the lungs?
Bleomycin
What is 1 enzyme treatment?
L - Asparaginase
What is 1 enzyme treatment?
L - Asparaginase
MOA for L - Asparaginase
Hydrolyzes L-Asparagine into aspartic acid and ammonia
= (-) protein synthesis
What is a common treatment for Acute Lymphoblastic Lymphoma (ALL)?
L - Asparaginase
What can L - Asparaginase treat?
ALL
Adverse side effects of L - Asparaginase?
Acute hypersensitivity reactions
Increased risk of clotting/bleeding and CNS toxicity
What does Imatinib treat?
CML - t(9;22) ((BCR-ABL))
MOA for Imatinib?
(-) ABL tyrosine kinase
What does Rituximab treat?
NHL
Diffuse large B cell lymphoma
MOA for Rituximab?
(-) CD20
Adverse effect of Rituximab?
Cytopenias
Ziv - Aflibercept (-) _____
VEGFR pathway
Ziv - Aflibercept (-) _____
VEGFR pathway
