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SBL > Cancer Pharmacology - Natural Products cont. > Flashcards

Cancer Pharmacology - Natural Products cont. Flashcards

1
Q

What are 2 Antibiotics?

A

Doxorubicin

Bleomycin

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2
Q

What are 2 Antibiotics?

A

Doxorubicin

Bleomycin

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3
Q

MOA for Doxorubicin? (multiple)

A

(-) Topoisomerase 2
(-) DNA synthesis
INCREASES free radicals

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4
Q

MOA for Doxorubicin? (multiple)

A

(-) Topoisomerase 2
(-) DNA synthesis
INCREASES free radicals

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5
Q

Adverse side effects of Doxorubicin?

A

Cardiotoxicity, red urine, etc.

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6
Q

What antibiotic can cause Cardiotoxicity?

A

Doxorubicin

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7
Q

MOA for Bleomycin

A

DNA strand breaks

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8
Q

Adverse side effects of Bleomycin?

A

Pulmonary toxicity - pneumonitis, cough, dyspnea, dry inspiratory crackles

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9
Q

Adverse side effects of Bleomycin?

A

Pulmonary toxicity - pneumonitis, cough, dyspnea, dry inspiratory crackles

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10
Q

What antibiotic can cause dry inspiratory crackles in the lungs?

A

Bleomycin

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11
Q

What is 1 enzyme treatment?

A

L - Asparaginase

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12
Q

What is 1 enzyme treatment?

A

L - Asparaginase

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13
Q

MOA for L - Asparaginase

A

Hydrolyzes L-Asparagine into aspartic acid and ammonia

= (-) protein synthesis

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14
Q

What is a common treatment for Acute Lymphoblastic Lymphoma (ALL)?

A

L - Asparaginase

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15
Q

What can L - Asparaginase treat?

A

ALL

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16
Q

Adverse side effects of L - Asparaginase?

A

Acute hypersensitivity reactions

Increased risk of clotting/bleeding and CNS toxicity

17
Q

What does Imatinib treat?

A

CML - t(9;22) ((BCR-ABL))

18
Q

MOA for Imatinib?

A

(-) ABL tyrosine kinase

19
Q

What does Rituximab treat?

A

NHL

Diffuse large B cell lymphoma

20
Q

MOA for Rituximab?

A

(-) CD20

21
Q

Adverse effect of Rituximab?

A

Cytopenias

22
Q

Ziv - Aflibercept (-) _____

A

VEGFR pathway

23
Q

Ziv - Aflibercept (-) _____

A

VEGFR pathway

SBL (48 decks)

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