HIV Pharm - PIs

Question 1

PI

Answer 1

Protease Inhibitors

Question 2

PIs are the +1 treatment for?

Answer 2

Experienced patients

Question 3

PIs are the +1 treatment for?

Answer 3

Experienced patients

Question 4

PIs prevent cleavage of?

Answer 4

HIV gag and pol precursors

Question 5

PIs are highly bound to?

Answer 5

Proteins

Question 6

What metabolizes PIs?

Answer 6

CYP3A4

Question 7

PIs are metabolized by?

Answer 7

Liver - CYP3A4

Question 8

Since PIs are metabolized by CYP3A4, what does that do to other drugs?

Answer 8

(-) metabolism of other drugs = increases their effects

Question 9

Since PIs are metabolized by CYP3A4, what does that do to other drugs?

Answer 9

(-) metabolism of other drugs = increases their effects

Question 10

Why is Saquinavir rarely used?

Answer 10

Pill burden

Question 11

Why is Saquinavir rarely used?

Answer 11

Pill burden

Question 12

Why is Indinavir rarely used?

Answer 12

Crystalluria/Renal stones

Question 13

Why is Indinavir rarely used?

Answer 13

Crystalluria/Renal stones

Question 14

Adverse effects of Darunavir?

Answer 14

Rash and hypersensitivities

Question 15

Adverse effects of Darunavir?

Answer 15

Rash and hypersensitivities

Question 16

Adverse effects of Atazanavir?

Answer 16

Jaundice

- Unconjugated hyperbilirubinemia

Question 17

Adverse effects of Atazanavir?

Answer 17

Jaundice

- Unconjugated hyperbilirubinemia

Question 18

What PIs are often taken with /c?

Answer 18

Darunavir

Atazanavir

Question 19

Most commonly used PIs?

Answer 19

Darunavir

Atazanavir

Question 20

What are 2 CYP3A4 inhibitors?

Answer 20

Ritonavir (/r)

Cobicistat (/c)

Question 21

Why are CYP3A4 inhibitors commonly taken with PIs?

Answer 21

PIs are metabolized by CYP3A4
– This decreases their effects and increases other drugs effects
= Taking CYP3A4 inhibitors will prolong the effects of PIs!!

Question 22

Why are CYP3A4 inhibitors commonly taken with PIs?

Answer 22

PIs are metabolized by CUP3A4
– This decreases their effects and increases other drugs effects
= Taking CYP3A4 inhibitors will prolong the effects of PIs!!

Question 23

What are 2 CYP3A4 inhibitors?

Answer 23

Ritonavir (/r)

Cobicistat (/c)

Question 24

What PIs are often taken with Cobicistat?

Answer 24

Darunavir

Atazanavir

Question 25

Darunavir and Atazanavir are commonly taken with what CYP3A4 inhibitor?

Answer 25

Cobicistat (/c)