HIV Pharm - PIs Flashcards
PI
Protease Inhibitors
PIs are the +1 treatment for?
Experienced patients
PIs are the +1 treatment for?
Experienced patients
PIs prevent cleavage of?
HIV gag and pol precursors
PIs are highly bound to?
Proteins
What metabolizes PIs?
CYP3A4
PIs are metabolized by?
Liver - CYP3A4
Since PIs are metabolized by CYP3A4, what does that do to other drugs?
(-) metabolism of other drugs = increases their effects
Since PIs are metabolized by CYP3A4, what does that do to other drugs?
(-) metabolism of other drugs = increases their effects
Why is Saquinavir rarely used?
Pill burden
Why is Saquinavir rarely used?
Pill burden
Why is Indinavir rarely used?
Crystalluria/Renal stones
Why is Indinavir rarely used?
Crystalluria/Renal stones
Adverse effects of Darunavir?
Rash and hypersensitivities
Adverse effects of Darunavir?
Rash and hypersensitivities
Adverse effects of Atazanavir?
Jaundice
- Unconjugated hyperbilirubinemia
Adverse effects of Atazanavir?
Jaundice
- Unconjugated hyperbilirubinemia
What PIs are often taken with /c?
Darunavir
Atazanavir
Most commonly used PIs?
Darunavir
Atazanavir
What are 2 CYP3A4 inhibitors?
Ritonavir (/r)
Cobicistat (/c)
Why are CYP3A4 inhibitors commonly taken with PIs?
PIs are metabolized by CYP3A4
– This decreases their effects and increases other drugs effects
= Taking CYP3A4 inhibitors will prolong the effects of PIs!!
Why are CYP3A4 inhibitors commonly taken with PIs?
PIs are metabolized by CUP3A4
– This decreases their effects and increases other drugs effects
= Taking CYP3A4 inhibitors will prolong the effects of PIs!!
What are 2 CYP3A4 inhibitors?
Ritonavir (/r)
Cobicistat (/c)
What PIs are often taken with Cobicistat?
Darunavir
Atazanavir
Darunavir and Atazanavir are commonly taken with what CYP3A4 inhibitor?
Cobicistat (/c)
