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SBL > Normal Hematopoiesis, Leukopenia/Leukocytosis > Flashcards

Normal Hematopoiesis, Leukopenia/Leukocytosis Flashcards

1
Q

What is the Cluster Designation (CD)?

A

Marker to allow identification of cell types

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2
Q

What can the Cluster Designation (CD) help diagnose?

A

Hematologic Malignancies

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3
Q

CD - TdT

A

Lymphoblasts (B and T cells)

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4
Q

CD19, CD20, PAX-5

A

B cells

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5
Q

CD16, CD56

A

NK cells

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6
Q

CD34

A

Myeloblasts (Neutrophils, basophils, eosinophils)

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7
Q

CD45

A

Leukocyte common antigen

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8
Q

Leukopenia

A

DECREASED WBCs

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9
Q

What are the WBCs?

A 
Neutrophils
Basophils
Eosinophils
Lymphocytes
Monocytes
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10
Q

Decreased WBCs

A

Leukopenia

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11
Q

Neutropenia

A

Decreased Neutrophils

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12
Q

Decreased Neutrophils

A

Neutropenia

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13
Q

Agranulocytosis

A

Marked reduction in WBCs

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14
Q

What is a normal range for WBC?

A

4.5-11

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15
Q

Leukopenia should be considered if the WBC count is below?

A

4.1 X 10^3

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16
Q

What does the differential give?

A

% of each WBC type

17
Q

How do you calculate Absolute Neutrophil Count (ANC)?

A

(% neutrophils + % bands) X WBC

18
Q

ANC < _____ puts people at risk for deadly _____ infections

A

ANC < 500

= Risk for bacterial and fungal infections

19
Q

Causes of Neutropenia?

A

Drug toxicity
Anemia
Hypersplenism
Immune destruction

20
Q

Treatment for Neutropenia?

A

Antibiotics

G-CSF

21
Q

Leukocytosis

A

INCREASED WBCs

22
Q

Increased WBCs

A

Leukocytosis

23
Q

4 causes of Leukocytosis

A
  1. Increased marrow production
  2. Increased release from marrow
  3. Decreased margination (adhesion to vessel walls)
  4. Decreased extravasation (leaving vessels)
24
Q

What can cause Neutrophilic Leukocytosis?

A

Bacterial infections

25
Q

What can cause Eosinophilic Leukocytosis?

A

Asthma
Parasitic infections
Drug reactions

26
Q

What can cause Lymphocytosis? (increased lymphocytes)

A

Viral infections

27
Q

With Leukocytosis, what portion of the lymph node often expands?

A

Germinal center

28
Q

Describe Acute Suppurative Lymphadenitis

A

Painful, pus forming

- Neutrophilic infiltrates seen in lymph nodes

29
Q

Most common form of Lymphadenitis?

A

Follicular Hyperplasia

30
Q

Describe Sinus Histiocytosis

A

Increased Macrophages in the lymph node sinuses

31
Q

Increased macrophages in the lymph node sinuses can be a sign of?

A

(Sinus Histiocytosis)

- Drainage of foreign material or malignancy

32
Q

What is an example of when Sinus Histiocytosis can occur?

A

Persistent lymphadenopathy after a tattoo!

33
Q

Germinal center expansion in the lymph nodes can indicate?

A

Leukocytosis (increased WBCs)

SBL (48 decks)

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