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SBL > Normal Hematopoiesis, Leukopenia/Leukocytosis > Flashcards

Normal Hematopoiesis, Leukopenia/Leukocytosis Flashcards

1
Q

What is the Cluster Designation (CD)?

A

Marker to allow identification of cell types

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2
Q

What can the Cluster Designation (CD) help diagnose?

A

Hematologic Malignancies

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3
Q

CD - TdT

A

Lymphoblasts (B and T cells)

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4
Q

CD19, CD20, PAX-5

A

B cells

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5
Q

CD16, CD56

A

NK cells

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6
Q

CD34

A

Myeloblasts (Neutrophils, basophils, eosinophils)

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7
Q

CD45

A

Leukocyte common antigen

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8
Q

Leukopenia

A

DECREASED WBCs

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9
Q

What are the WBCs?

A 
Neutrophils
Basophils
Eosinophils
Lymphocytes
Monocytes
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10
Q

Decreased WBCs

A

Leukopenia

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11
Q

Neutropenia

A

Decreased Neutrophils

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12
Q

Decreased Neutrophils

A

Neutropenia

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13
Q

Agranulocytosis

A

Marked reduction in WBCs

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14
Q

What is a normal range for WBC?

A

4.5-11

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15
Q

Leukopenia should be considered if the WBC count is below?

A

4.1 X 10^3

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16
Q

What does the differential give?

A

% of each WBC type

17
Q

How do you calculate Absolute Neutrophil Count (ANC)?

A

(% neutrophils + % bands) X WBC

18
Q

ANC < _____ puts people at risk for deadly _____ infections

A

ANC < 500

= Risk for bacterial and fungal infections

19
Q

Causes of Neutropenia?

A

Drug toxicity
Anemia
Hypersplenism
Immune destruction

20
Q

Treatment for Neutropenia?

A

Antibiotics

G-CSF

21
Q

Leukocytosis

A

INCREASED WBCs

22
Q

Increased WBCs

A

Leukocytosis

23
Q

4 causes of Leukocytosis

A
  1. Increased marrow production
  2. Increased release from marrow
  3. Decreased margination (adhesion to vessel walls)
  4. Decreased extravasation (leaving vessels)
24
Q

What can cause Neutrophilic Leukocytosis?

A

Bacterial infections

25
What can cause Eosinophilic Leukocytosis?
Asthma Parasitic infections Drug reactions
26
What can cause Lymphocytosis? (increased lymphocytes)
Viral infections
27
With Leukocytosis, what portion of the lymph node often expands?
Germinal center
28
Describe Acute Suppurative Lymphadenitis
Painful, pus forming | - Neutrophilic infiltrates seen in lymph nodes
29
Most common form of Lymphadenitis?
Follicular Hyperplasia
30
Describe Sinus Histiocytosis
Increased Macrophages in the lymph node sinuses
31
Increased macrophages in the lymph node sinuses can be a sign of?
(Sinus Histiocytosis) | - Drainage of foreign material or malignancy
32
What is an example of when Sinus Histiocytosis can occur?
Persistent lymphadenopathy after a tattoo!
33
Germinal center expansion in the lymph nodes can indicate?
Leukocytosis (increased WBCs)

SBL (48 decks)

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