Pruritus Treatments, Topical Vasoconstrictors and Ectoparasites

Question 1

What are some non-pharmacologic interventions for pruritus?

Answer 1

Moisture, cold environment, no skin irritants and reduced stress

Question 2

There are 6 topical therapies for Pruritus. Name them.

Answer 2

Calamine
Menthol and Camphor
Capsaicin
Hydrocortisone
Doxepin
Pramoxine

Question 3

MOA and effects of Calamine

Answer 3

MOA = unkown

- Calamine COOLs the skin

Question 4

MOA for Menthol and Camphor

Answer 4

Activates TRPM8 sensor

Question 5

What drugs for Pruritus can activate the TRPM8 sensor?

Answer 5

Menthol and Camphor

Question 6

Effects of Menthol and Camphor?

Answer 6

• Activate the TRPM8 sensor

= COOLs skin

Question 7

MOA for Capsaicin

Answer 7

Activates TRPV1 sensor

Question 8

What drug for Pruritus can activate the TRPV1 sensor?

Answer 8

Capsaicin

Question 9

Effects of Capsaicin

Answer 9

• Activates the TRPV1 sensor

= HEATs skin

Question 10

Capsaicin is effective at treating?

Answer 10

Neuropathic itch

Question 11

Hydrocortisone is a type of?

Answer 11

Corticosteroid

Question 12

What does Hydrocortisone help to treat?

Answer 12

Inflammatory skin dermatoses

Question 13

Doxepin is a type of?

Answer 13

Antihistamine

Question 14

What does Doxepin help to treat?

Answer 14

Histamin-induced itching – ex. bug bites

Question 15

Pramoxine is a type of?

Answer 15

Local anesthetic

Question 16

What does Pramoxine treat?

Answer 16

Pruritus of the face that is associated with CKD

Question 17

When treating pruritus, you should always start with what type of drugs?

Answer 17

HIGH potency to get the itching under control

Question 18

When treating pruritus, you always start with HIGH potency UNLESS?

Answer 18

Treating the face, genitals or skin folds

Question 19

When treating pruritus, you always start with HIGH potency UNLESS?

Answer 19

Treating the face, genitals or skin folds

Question 20

What is 1 callus and wart remover?

Answer 20

Salicylic Acid

Question 21

What does Salicylic acid do?

Answer 21

Removes calluses and warts

Question 22

What does Salicylic acid do?

Answer 22

Removes calluses and warts

Question 23

MOA for Salicylic acid

Answer 23

Inhibits COX

Question 24

Salicylic acid treats calluses and warts because it causes?

Answer 24

Epidermal cells to shed and the skin to soften

Question 25

Areas treated with Salicylic acid need?

Answer 25

Sun protection

Question 26

What are 4 topical vasoconstrictors?

Answer 26

Brimonidine Oxymetazoline Tetrahydrozoline Phenylephrine

Question 27

What are 4 topical vasoconstrictors?

Answer 27

Brimonidine Oxymetazoline Tetrahydrozoline Phenylephrine

Question 28

MOA for Brimonidine

Answer 28

Alpha 2 adrenergic agonist

Question 29

MOA for Oxymetazoline

Answer 29

Alpha 1A and 2 adrenergic agonist

Question 30

MOA for Tetrahydrozoline and Phenylephrine

Answer 30

Adrenergic receptor agonist

Question 31

What can Brimonidine and Oxymetazoline treat?

Answer 31

Rosacea

Question 32

What 2 topical vasoconstrictors can treat Rosacea?

Answer 32

Brimonidine | Oxymetazoline

Question 33

What can Oxymetazoline, Tetrahydrozoline and Phenylephrine treat?

Answer 33

Eyes

Question 34

What 3 topical vasoconstrictors can treat redness of the eyes?

Answer 34

Oxymetazoline Tetrahydrozoline Phenylephrine

Question 35

What do topical vasoconstrictors do?

Answer 35

Get the red out

Question 36

This drug can treat calluses and warts

Answer 36

Salicylic Acid

Question 37

This drug treats itching of the face that is associated with CKD

Answer 37

Pramoxine

Question 38

This drug treats itching such as bug bites

Answer 38

Doxepin

Question 39

This drug can treat neuropathic itch

Answer 39

Capsaicin

Question 40

What 3 drugs can cool the skin?

Answer 40

Calamine Camphor Menthol

Question 41

What are 4 drugs to treat Ectoparasites?

Answer 41

Malathion Permethrin Ivermectin Lindane

Question 42

What are 4 drugs to treat Ectoparasites?

Answer 42

Malathion Permethrin Ivermectin Lindane

Question 43

MOA for Malathion

Answer 43

Inhibits Cholinesterase | - treats ectoparasites

Question 44

MOA for Permethrin

Answer 44

Binds to Na+ channels to block membrane repolarization | - treats ectoparasites

Question 45

MOA for Ivermectin

Answer 45

Binds to Glutamate gated Cl- channels to hyperpolarize nerve and muscle cells - treats ectoparasites

Question 46

MOA for Lindane

Answer 46

Disrupts GABAergic transmission | - treats ectoparasites

Question 47

What is the most toxic/last resort treatment for Ectoparasites?

Answer 47

Lindane