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SBL > Pruritus Treatments, Topical Vasoconstrictors and Ectoparasites > Flashcards

Pruritus Treatments, Topical Vasoconstrictors and Ectoparasites Flashcards

1
Q

What are some non-pharmacologic interventions for pruritus?

A

Moisture, cold environment, no skin irritants and reduced stress

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2
Q

There are 6 topical therapies for Pruritus. Name them.

A 
Calamine
Menthol and Camphor
Capsaicin
Hydrocortisone
Doxepin
Pramoxine
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3
Q

MOA and effects of Calamine

A

MOA = unkown

- Calamine COOLs the skin

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4
Q

MOA for Menthol and Camphor

A

Activates TRPM8 sensor

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5
Q

What drugs for Pruritus can activate the TRPM8 sensor?

A

Menthol and Camphor

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6
Q

Effects of Menthol and Camphor?

A
  • Activate the TRPM8 sensor

= COOLs skin

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7
Q

MOA for Capsaicin

A

Activates TRPV1 sensor

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8
Q

What drug for Pruritus can activate the TRPV1 sensor?

A

Capsaicin

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9
Q

Effects of Capsaicin

A
  • Activates the TRPV1 sensor

= HEATs skin

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10
Q

Capsaicin is effective at treating?

A

Neuropathic itch

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11
Q

Hydrocortisone is a type of?

A

Corticosteroid

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12
Q

What does Hydrocortisone help to treat?

A

Inflammatory skin dermatoses

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13
Q

Doxepin is a type of?

A

Antihistamine

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14
Q

What does Doxepin help to treat?

A

Histamin-induced itching – ex. bug bites

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15
Q

Pramoxine is a type of?

A

Local anesthetic

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16
Q

What does Pramoxine treat?

A

Pruritus of the face that is associated with CKD

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17
Q

When treating pruritus, you should always start with what type of drugs?

A

HIGH potency to get the itching under control

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18
Q

When treating pruritus, you always start with HIGH potency UNLESS?

A

Treating the face, genitals or skin folds

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19
Q

When treating pruritus, you always start with HIGH potency UNLESS?

A

Treating the face, genitals or skin folds

20
Q

What is 1 callus and wart remover?

A

Salicylic Acid

21
Q

What does Salicylic acid do?

A

Removes calluses and warts

22
Q

What does Salicylic acid do?

A

Removes calluses and warts

23
Q

MOA for Salicylic acid

A

Inhibits COX

24
Q

Salicylic acid treats calluses and warts because it causes?

A

Epidermal cells to shed and the skin to soften

25
Q

Areas treated with Salicylic acid need?

A

Sun protection

26
Q

What are 4 topical vasoconstrictors?

A

Brimonidine
Oxymetazoline
Tetrahydrozoline
Phenylephrine

27
Q

What are 4 topical vasoconstrictors?

A

Brimonidine
Oxymetazoline
Tetrahydrozoline
Phenylephrine

28
Q

MOA for Brimonidine

A

Alpha 2 adrenergic agonist

29
Q

MOA for Oxymetazoline

A

Alpha 1A and 2 adrenergic agonist

30
Q

MOA for Tetrahydrozoline and Phenylephrine

A

Adrenergic receptor agonist

31
Q

What can Brimonidine and Oxymetazoline treat?

A

Rosacea

32
Q

What 2 topical vasoconstrictors can treat Rosacea?

A

Brimonidine

Oxymetazoline

33
Q

What can Oxymetazoline, Tetrahydrozoline and Phenylephrine treat?

A

Eyes

34
Q

What 3 topical vasoconstrictors can treat redness of the eyes?

A

Oxymetazoline
Tetrahydrozoline
Phenylephrine

35
Q

What do topical vasoconstrictors do?

A

Get the red out

36
Q

This drug can treat calluses and warts

A

Salicylic Acid

37
Q

This drug treats itching of the face that is associated with CKD

A

Pramoxine

38
Q

This drug treats itching such as bug bites

A

Doxepin

39
Q

This drug can treat neuropathic itch

A

Capsaicin

40
Q

What 3 drugs can cool the skin?

A

Calamine
Camphor
Menthol

41
Q

What are 4 drugs to treat Ectoparasites?

A

Malathion
Permethrin
Ivermectin
Lindane

42
Q

What are 4 drugs to treat Ectoparasites?

A

Malathion
Permethrin
Ivermectin
Lindane

43
Q

MOA for Malathion

A

Inhibits Cholinesterase

- treats ectoparasites

44
Q

MOA for Permethrin

A

Binds to Na+ channels to block membrane repolarization

- treats ectoparasites

45
Q

MOA for Ivermectin

A

Binds to Glutamate gated Cl- channels to hyperpolarize nerve and muscle cells
- treats ectoparasites

46
Q

MOA for Lindane

A

Disrupts GABAergic transmission

- treats ectoparasites

47
Q

What is the most toxic/last resort treatment for Ectoparasites?

A

Lindane

SBL (48 decks)

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