Detection and Diagnosis of Malignancy Flashcards

1
Q

4 signs that a primary tumor is present?

A
  1. Sensation of a mass
  2. Invasion of adjacent structures
  3. Obstruction
  4. Compression
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2
Q

4 signs that a primary tumor is present?

A
  1. Sensation of a mass
  2. Invasion of adjacent structures
  3. Obstruction
  4. Compression
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3
Q

2 cancers that may be palpable or cause a sensation of a mass?

A

Breast cancer

Soft-tissue sarcomas

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4
Q

What type of invasion from a primary tumor is more concerning for malignancy?

A

Skin invasion

ex. breast cancer

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5
Q

There are many options for tumors to cause obstruction. What is an example of a tumor that can cause airway obstruction?

A

Lung carcinoma growing endobronchially

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6
Q

Signs that a tumor is causing airway obstruction?

A

Stridor

Downstream lung tissue is collapsed

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7
Q

What is Superior Vena Cava Syndrome?

A

When a primary tumor is obstructing the superior vena cava from draining into the heart

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8
Q

Symptoms of Superior Vena Cava Syndrome?

A

Venous distention of neck and chest wall

Facial and upper arm edema

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9
Q

Venous distention of neck and chest wall, as well as facial and upper arm edema can suggest what type of tumor obstruction?

A

Superior Vena Cava Syndrome

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10
Q

What physical sign will be positive with Superior Vena Cava Syndrome?

A

Pemberton’s sign

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11
Q

Describe Pemberton’s sign

A

Exaggeration of Superior Vena Cava Syndrome findings when the arms are raised above the head

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12
Q

Exaggeration of SVC syndrome when the arms are raised above the head is what sign?

A

Pemberton’s sign

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13
Q

What is the most common type of compression from a primary tumor?

A

Spinal cord compression

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14
Q

Another sign of a primary tumor may be abnormal _____

A

Bleeding!

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15
Q

Post-menopausal women “menstruating again” may suggest?

A

Uterine/endometrial cancer

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16
Q

Blood should never be present in bodily fluids. Besides that symptom, what is another sign of hemorrhage?

A

Pain!

- often caused by ABRUPT hemorrhage

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17
Q

Chronic bleeding can manifest as?

A

Iron deficient anemia

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18
Q

Tumor cells can also irritate?

A

Peritoneum and pleural space

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19
Q

If an ovarian carcinoma irritates the peritoneum, what is an example of how that will present?

A

Ovarian carcinoma –> ASCITES

20
Q

If a tumor irritates the pleural space, what will that cause to form?

A

Malignant pleural effusion

21
Q

What measures can provide both therapeutic and diagnostic value to effusions?

A

Thoracentesis and Paracentesis

22
Q

Low protein and low cell count effusion

A

Transudative

23
Q

High protein and high cell count effusion

A

Exudative

24
Q

History taking, Physical exam and Lab testing can all suggest different aspects of primary tumor presentation. What can catch all of them?

A

Radiography

25
Q

Cancer staging pneumonic

A

TNM

  • Tumor size
  • Nodal involvement
  • Metastasis extent
26
Q

4 types of metastatic spread?

A
  1. Lymphatic
  2. Hematogenous
  3. Transcoelomic
  4. Canalicular
27
Q

Transcoelomic spread?

A

Invades the serosa

28
Q

Canalicular spread?

A

Travels along pre-existing duct/lumen

29
Q

What types of cancers spread through the lymphatics usually?

A

Carcinomas

30
Q

Carcinomas usually spread via?

A

Lymphatics

31
Q

What types of cancers spread through hematogenous (blood)?

A

Sarcomas and advanced carcinomas

32
Q

Sarcomas usually spread via?

A

Hematogenous spread (blood)

33
Q

Advanced carcinomas can also spread via?

A

Hematogenous spread (blood)

34
Q

On physical exam to check for metastasis you should check?

A

Lymph nodes

35
Q

With lung carcinoma, checking hilar and mediastinal lymph nodes requires?

A

Radiography

36
Q

Describe how to know what lymph nodes must be dissected from metastatic cancer spread?

A
  • Inject radiotracer dye into tumor
  • Dye will spread to sentinel node first
  • Take out the involves nodes with the dye in them
37
Q

Common metastatic cancer symptoms?

A

Fatigue and weight loss
Bone/back pain
Neurological symptoms
Compression/obstruction

38
Q

What is a Sister Mary Joseph Nodule?

A

Umbilical metastasis from ovarian carcinoma

39
Q

What causes a Sister Mary Joseph Nodule?

A

Ovarian carcinoma

40
Q

Umbilical metastasis is considered a?

A

Sister Mary Joseph Nodule

41
Q

What is Virchow’s node?

A

Left supraclavicular lymphadenopathy from ANY thoracic or abdominal carcinoma

42
Q

What causes Virchow’s node?

A

ANY thoracic or abdominal carcinoma

43
Q

Where is Virchow’s node?

A

Left supraclavicular lymphadenopathy

44
Q

Why is Virchow’s node where it is?

A

It is near the site of where the thoracic duct (that drains 3/4 of the body’s lymph) drains into the subclavian vein

45
Q

Recurrences of cancer are typically _____

A

Metastatic