Cancer Pharmacology - Natural Products

Question 1

What are 2 Vinca Alkaloids?

Answer 1

Vinblastine

Vincristine

Question 2

What are 2 Vinca Alkaloids?

Answer 2

Vinblastine

Vincristine

Question 3

Vinblastine and Vincristine act during which cell cycle phase?

Answer 3

M phase

Question 4

MOA for Vinca Alkaloids (Vinblastine and Vincristine)

Answer 4

Binds to beta-tubulin to (-) microtubule assembly

Question 5

Adverse effects of Vinca Alkaloids (Vinblastine and Vincristine)?

Answer 5

Alopecia

Bone marrow suppression

Question 6

Vinblastine major side effect?

Answer 6

Myelosuppression

Question 7

Vincristine major side effect?

Answer 7

Neurological toxicities

Question 8

What is 2 Taxanes?

Answer 8

Paclitaxel

Carbazitaxel

Question 9

What is 2 Taxanes?

Answer 9

Paclitaxel

Carbazitaxel

Question 10

Paclitaxel acts during which cell cycle phase?

Answer 10

M phase

Question 11

MOA for Paclitaxel (taxane)

Answer 11

Binds to beta-tubulin and (+) microtubule assembly

Question 12

Adverse effects of Paclitaxel?

Answer 12

Hypersensitivity reactions to hands/toes and changes in taste

Question 13

What is 1 Camptothecin?

Answer 13

Topotecan

Question 14

What is 1 Camptothecin?

Answer 14

Topotecan

Question 15

MOA for Topotecan

Answer 15

(-) Topoisomerase 1

= DNA damage and cell death

Question 16

Adverse effect of Topotecan?

Answer 16

Diarrhea

Question 17

What can treat the adverse side effect of Topotecan?

Answer 17

• Diarrhea

= Atropine

Question 18

What is 1 Epipodophyllotoxin?

Answer 18

Ectoposide

Question 19

What is 1 Epipodophyllotoxin?

Answer 19

Ectoposide

Question 20

MOA for Ectoposide?

Answer 20

(-) Topoisomerase 2

= DNA damage

Question 21

P-Glycoprotein often confers resistance to natural product chemotherapeutics. What Taxane can avoid this?

Answer 21

Carbazitaxel (taxane)

Question 22

P-Glycoprotein often confers resistance to natural product chemotherapeutics. What drug can avoid this?

Answer 22

Carbazitaxel (taxane)