Cancer Pharmacology - Natural Products Flashcards
What are 2 Vinca Alkaloids?
Vinblastine
Vincristine
What are 2 Vinca Alkaloids?
Vinblastine
Vincristine
Vinblastine and Vincristine act during which cell cycle phase?
M phase
MOA for Vinca Alkaloids (Vinblastine and Vincristine)
Binds to beta-tubulin to (-) microtubule assembly
Adverse effects of Vinca Alkaloids (Vinblastine and Vincristine)?
Alopecia
Bone marrow suppression
Vinblastine major side effect?
Myelosuppression
Vincristine major side effect?
Neurological toxicities
What is 2 Taxanes?
Paclitaxel
Carbazitaxel
What is 2 Taxanes?
Paclitaxel
Carbazitaxel
Paclitaxel acts during which cell cycle phase?
M phase
MOA for Paclitaxel (taxane)
Binds to beta-tubulin and (+) microtubule assembly
Adverse effects of Paclitaxel?
Hypersensitivity reactions to hands/toes and changes in taste
What is 1 Camptothecin?
Topotecan
What is 1 Camptothecin?
Topotecan
MOA for Topotecan
(-) Topoisomerase 1
= DNA damage and cell death
Adverse effect of Topotecan?
Diarrhea
What can treat the adverse side effect of Topotecan?
- Diarrhea
= Atropine
What is 1 Epipodophyllotoxin?
Ectoposide
What is 1 Epipodophyllotoxin?
Ectoposide
MOA for Ectoposide?
(-) Topoisomerase 2
= DNA damage
P-Glycoprotein often confers resistance to natural product chemotherapeutics. What Taxane can avoid this?
Carbazitaxel (taxane)
P-Glycoprotein often confers resistance to natural product chemotherapeutics. What drug can avoid this?
Carbazitaxel (taxane)
