USMLE Rx Questions: Week 06/06/16

Question 1

Schizophrenia is associated with the __________ pathways.

Answer 1

mesolimbic and mesocortical

Question 2

List three symptoms of amiodarone toxicity, and the thread that unifies them.

Answer 2

Hypothyroidism can result from amiodarone use:
Fatigue
Constipation
Weight gain

Question 3

Amiodarone mimics _________ and prevents its activation to _______.

Answer 3

T4; T3

Question 4

What are normal calcium levels?

Answer 4

8.5 - 10.2 mg/dL

Question 5

Briefly list the pathogenesis and presentation of Paget’s disease.

Answer 5

Paget’s disease, also called osteitis deformans, results from increased osteoclast activity followed by increased osteoblast activity. This leads to poor bone formation, which presents with pain and mosaic bone pattern. All labs will be normal, with the exception of elevated Alk-Phos.

Question 6

What are normal levels of alkaline phosphatase?

Answer 6

44 - 147 IU/L

Question 7

In severe Paget’s disease, patients can develop _________, which can lead to high-output CHF.

Answer 7

hypervascularity of the bones (which behaves like an arteriovenous shunt)

Question 8

The most serious complication of juvenile rheumatoid arthritis is ___________.

Answer 8

blindness due to uveitis

Question 9

Which seizure drug can lead to Steven-Johnson syndrome?

Answer 9

Lamotrigine

Question 10

Importantly, fibrosis of myocytes will lead to _________ cardiomyopathy.

Answer 10

restrictive

Question 11

Rapidly progressive glomerulonephritis is associated with two sources of nephritic syndrome: _____________.

Answer 11

ANCA and Goodpasture’s

Question 12

Lupus is most associated with which type of nephritic syndrome?

Answer 12

Diffuse proliferative glomerulonephritis

Question 13

Which drug is given to lupus patients with significant organ involvement?

Answer 13

Cyclophosphamide

Question 14

Histologically, what is unique about Langerhans cell histiocytosis?

Answer 14

They contain Birbeck granules (the tennis-racket sign on electron microscopy)

Question 15

What are two cell surface markers for dendritic cells?

Answer 15

S-100 and CD-1a

Question 16

Vincristine and vinblastine are __________ inhibitors.

Answer 16

macrotubule formation

Question 17

Lead poisoning can lead to _________ stippling.

Answer 17

basophilic

Question 18

Which enzyme does lead poisoning inhibit?

Answer 18

ALA dehydratase

Question 19

List two big signs of bleomycin poisoning.

Answer 19

Skin pigmentation and pulmonary fibrosis

Question 20

What drug is used to diagnose and treat supraventricular arrhythmia?

Answer 20

Adenosine

Question 21

Dibetes insipidus does not cause _______-natremia.

Answer 21

hypo

Question 22

A common blood smear finding in those with multiple myeloma is ______________.

Answer 22

stacked RBCs

Question 23

People with anticentromere antibodies typically have CREST symptoms. What are they?

Answer 23

Calcinosis of the skin
Raynaud 
Esophageal dysfunction 
Scleroderma 
Telangiectasia

Question 24

Contact dermatitis is a type ______ immunological reaction.

Answer 24

IV

Question 25

The most common type of tumor in the pituitary area is ____________.

Answer 25

craniopharyngioma

Question 26

The most common extra-articular manifestation of gout is _____________.

Answer 26

gouty nephropathy

Question 27

The trabeculated parts of the heart come from ____________.

Answer 27

primitive atria and primitive ventricles

Question 28

T-ALL typically presents in _________ with a thymic mass and cells positive for ____________.

Answer 28

adolescent males; terminal deoxynucleotidyl transferase (TdT)

Question 29

TdT is a marker of ____________.

Answer 29

pre-B and pre-T cells

Question 30

What are the three most common causes of cancer death in men?

Answer 30

Lung, prostate, colorectal

Question 31

What blood pressure medicine can cause fatigue and depression?

Answer 31

Clonidine

Question 32

Alpha-1-antitrypsin deficiency can lead to what sign in the liver?

Answer 32

Intracellular acid-Schiff-positive globules

Question 33

Tamoxifen inhibits the estrogen-dependent synthesis of ___________.

Answer 33

TGF-beta

Question 34

What are Howell-Jolly bodies and in what disease do they present?

Answer 34

Remnants of nuclei; sickle cell (because of splenic dysfunction)

Question 35

Tamoxifen and raloxifen work by ____________. What side effect are they different in?

Answer 35

being selective estrogen receptor modulators (though tamoxifen is the only anti-neoplastic); tamoxifen increases risk of endometrial cancer by being an agonist in the endometrium, while raloxifen does not