Sketchy Pharm: Vancomycin Flashcards
Vancomycin is only effective against _____________.
Gram-positive organisms (represented by the purple dots on the hills)
What residue does vancomycin bind?
The D-Ala D-Ala residue
Think of Indiana Jones’ rope binding directly to the archway with DALA written all over it.
Vancomycin is almost always administered ________________.
intravenously (like the IVy that Indiana is swinging on)
Vancomycin is frequently combined with ___________ to empirically treat meningitis.
ceftriaxone
Think of the native wearing the red trojan helmet.
What disease is represented by things strewn in the sand?
MRSA osteomyelitis (because fishbones are scattered near the van)
Vancomycin is frequently used for nosocomial _____________.
MRSA pneumonia (like the nurse coughing near the van)
Recall that vancomycin is used to treat a heart valve infection: ________________.
Staphylococcus epidermidis endocarditis
How do organisms (such as Enterococcus faecium) develop resistance to vancomycin?
They alter D-Ala D-Ala to D-Ala D-Lac.
Think of the alternate tomb with the different hieroglyphs.
What are some side effects of vancomycin?
Red man syndrome (flushing due to mast cell degranulation) –this can be alleviated by prolonging the infusion; thrombophlebitis; ototoxicity; nephrotoxicity; and Dress syndrome
(Think of the red statue with blue vines on its legs –red man and thrombophlebitis –and a cracked ear. Also, there is a cracked, kidney-shaped plate falling by a woman in a pink dress.)
