Pathoma: Tumor Progression

Question 1

The first step of tumor spread is _______.

Answer 1

loss of E-cadherin, which adheres tumor cells to one another

Question 2

The basement membrane is composed of ________.

Answer 2

collagen IV and laminin V

Question 3

List Sattar’s steps for tumor spread.

Answer 3

(1) down regulation of E-cadherin; (2) attachment to the laminin of the basement membrane; (3) secretion of MMPs; (4) attachment to fibronectin within the ECM; (5) intravasation to the lymph nodes or blood vessels

Question 4

__________ usually spread via the lymphatics, while __________ usually spread hematogenously.

Answer 4

Carcinomas (with the exceptions of renal cell, hepatocellular, choriocarcinoma, and follicular carcinoma of thyroid); sarcomas