Pathoma: CNS Tumors Flashcards
Where do metastatic lesions develop in the brain?
At the gray-white junction
What cells make up the meninges?
Meningothelial cells
What are the most common primary CNS tumors in kids and adults?
Kids: pilocytic astrocytoma
Adults: glioblastoma multiforme
A tumor without IDH mutations and with PTEN mutations commonly crosses the ____________.
corpus callosum (this is glioblastoma multiforme)
What does palisading mean?
Lining up
What type of protein is GFAP?
An intermediate filament
Meningiomas are neoplasms of which layer?
The arachnoid
Why does meninioma occur more often in females?
Because meningiomas express estrogen receptors
What molecule do Schwannomas display?
S100
Where do oligodendrogliomas typically present?
In the frontal lobe as a seizure-causing, calcified mass
How are the rosettes in ependymoma different from medulloblastoma?
The ependymal rosettes line blood vessels
Explain the unusual embryology of the pituitary gland.
The anterior part arises from a pouch in the pharynx while the posterior part arises from the brain.
Bitemporal hemianopsia in a child suggests ____________.
craniopharyngioma (pressing on the optic chiasma – pituitary tumors more common in adults)
