Sketchy Micro: Reovirus (dsRNA)

Question 1

What covering does reovirus have?

Answer 1

It is naked (represented by the David-shaped rock).

Question 2

What genetic makeup does reovirus have?

Answer 2

It is dsRNA.

The orange tones represent RNA, and the double-helical lane divider shows that it is double.

Question 3

How many segments does reovirus have?

Answer 3

First off, remember that it is segmented just like Bunyavirus and Orthomyxovirus. Second, reovirus can have between nine and eleven segments.

(Sketchy shows the segmentation by illustrating 11 boats on the river.)

Question 4

One of the most common reoviruses is ______________.

Answer 4

rotavirus (like the rotor on the back of the boat to the left of the scene)

Question 5

What toxin causes diarrhea in rotavirus?

Answer 5

NSP4, a viral enterotoxin that increases chloride permeability

(The rotor says “Nine SPeed –4 stroke” and the boat is called CHLO-RIDEr.)

Question 6

Rotavirus is most common during ___________.

Answer 6

winter (represented by the snowy peaks)

Question 7

Rotavirus is the number-one cause of _____________.

Answer 7

severe diarrhea in young children

Question 8

What virus other than rotavirus is part of the reovirus family?

Answer 8

Colorado Tick virus (like the giant tick on the “Welcome to Colorado” sign)

Question 9

How can you distinguish Colorado Tick virus from Rickettsia?

Answer 9

Rickettsia presents with a rash

CTV presents with myalgias, vomiting, and fever (like the kid on the riverbank)

Question 10

What kind of vaccine is the rotavirus vaccine?

Answer 10

Live attenuated oral (like the cameraman recording LIVE on the shore with a needle-shaped microphone holding it next to his mouth)