Sketchy Micro: Shigella Flashcards
What kind of bacteria is Shigella?
Gram-negative, rod-shaped enteric
On a Hektoen agar, Shigella is distinct from Salmonella because ______________.
Shigella grows green colonies (like the she-gorilla’s green tutu), while Salmonella grows black colonies (like the black plate that the salmon was on)
Shigella is distinct from Salmonella is two other ways: ______________.
it is immotile (represented by the she-gorilla’s chain) and it is acid-resistant (represented by the other she-gorilla walking the tightrope over the acid)
How does Shigella invade the GI tract?
It gets taken up by M cells, but before the phagolysosome can destroy them, Shigella use actin to shoot themselves into neighboring enterocytes.
(Think of the she-gorilla shot out of the cannon labeled “M”.)
Because it invades enterocytes, shigella causes ________________.
inflammatory diarrhea with blood (symbolized by the red stool that the she-gorilla is sitting on)
Describe shigellosis.
Most commonly occurring in children younger than age 10, shigellosis results from Shiga toxin that damages endothelium, particularly that of the glomerulus. This damaged endothelium leads to schistocytes, anemia, and thrombocytopenia.
(Think of the young boy whipping the RBC balloons with the glomerulus-shaped rope.)
Which protein does Shiga toxin target?
The 60S subunit (think of the 60 Second timer for the circus act, represented by the hourglass)
Like Salmonella enteriditis, Shigella utilizes a ____________.
type 3 secretion system
