Sketchy Pharm: Cholinomimetics Flashcards

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1
Q

Cholinomimetics mimic ____________; they are also called parasympathomimetics.

A

acetylcholine (“enjoy an acetyl-Cola”)

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2
Q

The Gq receptors couple to the ________ pathway.

A

IP3-DAG (think of the three dogs riding with the man on the motorcycle)

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3
Q

Where do M2 muscarinic channels affect the heart?

A

The atria – specifically through the SA and AV nodes (think of the girl with the lower part of her jacket torn off)

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4
Q

Where do M3 channels exist?

A

The smooth muscles and glands (think of the rear-most motorcycle rider with the smooth-muscle paint job and glandular sponge)

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5
Q

Why does M3 activation lead to vasodilation?

A

Because the receptor also activates NO; without this (such as in the case of endothelial cell damage) muscarinic agonists do lead to vasoconstriciton

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6
Q

In what circumstances do you administer bethanecol?

A

For non-obstructive bowel and bladder disorders (such as post-op ileus, megacolon, or neurogenic bladder); think of beth the construction worker pouring cement next to the “do not obstruct” sign

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7
Q

Muscarinic agonists _________ intraocular pressure.

A

reduce

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8
Q

What is the main use of pilocarpine?

A

Stimulate salivary glands (useful for those with Sjögren’s or radiation damage) and reduce IOP for glaucoma

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9
Q

What cholinergic receptors does carbacol stimulate?

A

Both nicotinic and muscarinic – think of the guy inhaling the cigarette smoke from below while looking at the motorcycles

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10
Q

In addition to aggravating asthma and COPD, what disorder can cholinomimetics aggravate?

A

Peptic ulcer disease (think of methacholine)

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