Sketchy Micro: Papillomavirus

Question 1

Genetically, what kind of virus is papillomavirus?

Answer 1

dsDNA (think of the blue overtones –like the blue table that the lovers are sitting at)

Question 2

What covering does papillomavirus have?

Answer 2

It is naked (like the statue of David)

Question 3

Verruca vulgaris is caused by ____________.

Answer 3

HPV 1-4

(Think of the four-year-old boy and the one-year-old holding up four fingers and one finger, respectively: they’re covered in pill bugs that represent the common wart.)

Question 4

What diseases can be caused by HPV 6 and 11?

Answer 4

Laryngeal papillomatosis and urogenital warts (aka condyloma acuminata)

(Think of the two boys –one 6 and the other 11 – tossing pillbugs in their shorts and down their throat.)

Question 5

Laryngeal papillomatosis is thought to be acquired at ________________.

Answer 5

birth (from vaginal infection)

Question 6

Which strains of HPV are cancer-causing?

Answer 6

16, 18, 31, and 33

(Think of the 16-year-old and 18-year-old eating crab dinner–there are car keys signifying the 16-year-old and an “I voted” sticker symbolizing the 18-year-old. To get the others, just add 15 to each!)

Question 7

_____________ is a vaccine against HPV.

Answer 7

Gardasil (like the syringe-topped fence that is guarding the property)

Question 8

Which HPV strains are not covered by Gardasil 9?

Answer 8

1-4 (like how the kids are outside the guarded area)

Question 9

What proteins allow HPV to cause cancer?

Answer 9

E6 causes the proteolysis of p53. E7 causes the proteolysis of RB.

This prevents the G1S checkpoint.

(Think of the fork in the shrimp that looks like “E6” and the fork and straw that look like “E7” in the Root Beer.)

Question 10

What cells are pathognomonic for cervical cancer (and HPV infection more generally)?

Answer 10

Koilocytes (like the weird fried egg with the blue yolk that the girl is eating)