Sketchy Pharm: ADH, DDAVP, ADH Receptor Antagonists Flashcards
ADH is released by the _______________.
posterior pituitary (like how the ADH waterboy has the water on his back –his posterior side)
ADH activates V1 receptors. What kind of receptor is this and what does it do?
It is a Gq receptor that leads to vasoconstriction.
Think of the Q-shaped mound that the V1 hole is on and how the golfer there is bending –constricting –his golf club.
Where are V2 receptors located? What do they do? What kind of receptor are they?
V2 receptors are Gs proteins on the basolateral side of the collecting duct. Activation leads to increased cAMP that causes aquaporin channels to insert into the apical membrane and absorb free water.
Which kind of vasopressin receptor mediates the release of Von Willebrand factor?
V2 –like how there are two people playing pool on the Von Wille Brand-sponsored pool table.
Also, remember that this causes the release of factor VIII –like the 8 ball that the waterboy is aiming for.
Lithium causes _____________ diabetes insipidus.
nephrogenic (think of how the guy with the LIftium balloons is closer to the kidney sand trap)
What drug can treat nephrogenic DI?
Thiazides, because they reduce plasma volume and cause increased NaCl absorption in the proximal convoluted tubule
(Think of the thiazide speedo boy retrieving the golf ball.)
What drug blocks lithium entry into collecting duct cells?
Amiloride (represented by the amiloride almond cart that is pushing the LIftium balloon man out of the way)
How do NSAIDs treat nephrogenic DI?
They decrease GFR, thereby slowing the effects of nephrogenic DI.
(Think of the NSAID fire extinguisher behind the almond cart man.)
Central DI can be caused by ______________.
trauma, neoplasm, or autoimmune disorders
How is central DI treated?
DDAVP (represented by the waterboys on the DESert MObile cart, coming to the rescue)
Desmopressin primarily affects the _______ receptor.
V2 (like the V2-engine of the DESert MObile cart with two cylinders)
Because DDAVP targets V2 receptors, it can also be used to treat __________________.
Von Willebrand disease and factor VIII deficiency (like the cart driving over the Von Wille Brand pool table –leaving 2 tracks –and knocking out the 8 ball)
Because DDAVP leads to increased aquaporins in the collecting duct, it can also be used to treat ___________.
enuresis (symbolized by the wet mattress being pulled by the DESert MObile cart)
Exogenous ADH (vasopressin) can, relying on its vasoconstrictive properties, treat ____________.
esophageal varices, because it constricts the mesenteric arterioles
(Think of the ADH waterboy on the V1 green holding a bag that looks like an esophagus with dilated blue clubs.)
SIADH can be treated with _____________.
the -vaptan drugs: tolvaptan and conivaptan (think of the boy riding in on the bicycle spraying the ADH waterboy –who is inappropriately spraying golfers with water –with his VAPorizer watergun); it can also be treated with demeclocycline (like the bike he’s riding in on)
