Sketchy Pharm: Glucocorticoids Flashcards
Where (in the cell) are glucocorticoid receptors located?
In the cytosol
(Think of how the scepter – symbolic of the receptor –is initially outside the inner circle, but once it binds the moon it enters.)
The receptor-glucocorticoid complex binds to _____________.
promoter sequences for a number of genes; these sequences are called GREs: glucocorticoid response elements
How do glucocorticoids inhibit COX and LOX?
By inhibiting PLC A2 (like the cAtApult that is being hexed by the druid priest)
Glucocorticoids inhibit what transcription factor?
NF-kappa B, which normally promotes TNF-alpha and IL-2
Think of the iNFlamed KrossBow that is being stopped by the druid magic.
Inhibiting NF-kB stops what two cell types?
T and B cells (like the antibody archer and T-cell knight)
How do glucocorticoids cause neutrophilia?
They decrease migration and prevent adhesion.
Think of the neutro-first responders –with stretchers –who are unable to make it into the ring of stones.
Steroids cause decreased counts of which cell types?
T cells
B cells
Eosinophils
(Think of the falling antibody archer, T-cell knight, and eo-slingshot boy.)
Steroids can cause insulin _____________.
resistance (like the knight who can’t enter the ring over the “welcome inside” mat)
How does Sketchy illustrate the contrary effects that corticosteroids have on blood sugar?
Sketchy shows how cortisol raises gluconeogenesis by the druid that is taking candy from a liver-shaped bag and putting it on the pedestal, and they also show how glycogen stores are increased by the liver jar filled with candy.
Exogenous corticosteroid use does what to the adrenals?
Causes atrophy
Think of the druid with the shriveled hat who’s fallen over due to adrenal insufficiency after stopping steroid use.
What effect does glucocorticoid have on protein and fat?
It promotes proteolysis and lipolysis (like the meat and doughnuts falling off the table)
Corticosteroids can cause reactivation of latent infections, most worryingly _____________.
TB; recurrent TB usually affects the upper lobes, just like how the Sketchy TB cactus only has the upper portions affected
Adrenal insufficiency leads to ________-glycemia.
hypo (represented by the falling man with the spilling candy)
