Pathoma: Leukopenia and Leukocytosis

Question 1

CD34 is found on ________.

Answer 1

all hematopoietic cells

Question 2

Broadly, neutropenia can arise from _________.

Answer 2

toxins (chemotherapy), severe infection, and genetic disorders

Question 3

High cortisol induces ______ in lymphocytes.

Answer 3

apoptosis

Question 4

Immunologically speaking, lupus leads to ____________.

Answer 4

autoimmune lymphopenia

Question 5

List the four sources of neutrophilic leukocytosis.

Answer 5

Bacterial infection, tissue necrosis, high cortisol state, and genetic disorders (LAD and CGD)

Question 6

Describe why cortisol induces neutrophilia.

Answer 6

There are neutrophils adhered (marginated) to the endothelial walls. Steroids cause them to release.

Question 7

Other than allergic reactions and parasitic infections, what else causes eosinophilia?

Answer 7

Hodgkin’s lymphoma

Question 8

Basophilia is associated with _____.

Answer 8

CML

Question 9

The one bacteria where you’d expect lymphocytic leukocytosis (as opposed to neutrophilia) is _______.

Answer 9

bortadella pertussis

Question 10

Where in the spleen are the T lymphocytes located?

Answer 10

In the periarterial lymphatic sheath (PALS) – part of the white pulp that surrounds the incoming arteries

Question 11

Why is infectious mononucleosis (mono) called mononucleosis?

Answer 11

Because the T cells expand and resemble monocytes

Question 12

Mononucleosis leads to ________.

Answer 12

hepatomegaly and splenomegaly (increasing the risk of splenic rupture)