U World Assesment 1

Question 1

Recent trauma, white looking lung (pulm opaciety) with normal sized heart

Answer 1

could be ARDS

Question 2

What is the cause of ARDS

Answer 2

injury to pneumocytes and pulmanry endothilum

Question 3

What does DM nephropathy look like

Answer 3

Mesangial Expansion
Basement membrane thickining
Glomerular Sclerosis

Question 4

Speed of conduction through the heart

Answer 4

Fastest- Perkingie (in ventricles) -> Atria -> Ventricles-> AV node (R atria) -Slowest

Park AT Ventricular AVenue

Question 5

Heart Conduction Pathyway

Answer 5

SA (atria) –> AV (tricuspid)–> Bundle of his–> L/R Bundle Branch –> Perkingie–> Vent. Muscle

Question 6

Tumor most often seen in Paget of bone

Answer 6

Osteosarcoma

“periosteal elevation” or Sun Burst Pattern

Question 7

What do Proteases cleave

Answer 7

Protein tagged with ubiquitin

Question 8

A “Ladder” of DNA on gel electropheisis

Answer 8

Apoptosis- Cleaves DNA into 180 base pairr bits, leading to equal ladder aperence on gel

Question 9

What is pheostigmine

Answer 9

cholinesterase inhibitor

aka increases AcH

Atropine will reverse its effect

Question 10

Side effects of Atropine

Answer 10

Hot as a hare ( increased body temp) 
Dry as a bone (dry mouth, skin, etc) 
Red as a beet (flushed) 
Blind as a bat ( cycloplegia) 
Mad as a hatter (AMS) 

Jimson weed is drug of abuse that will also lead to this (acts same as atropine)

Question 11

Why does atropine increase body temp

Answer 11

decreased sweating

Question 12

Achondroplasia demonstrates what kind of penetrance

Answer 12

complete penetrance

Question 13

Translocation for Burkitt Lymphoma

Answer 13

t(8:14)

Question 14

CML translocation

Answer 14

t (9:22)

Question 15

ALL translocation

Answer 15

t (12:21)

Question 16

Follicular lymphoma translocation

Answer 16

t (14:18)

Question 17

Which disease shows auer rods

Answer 17

APML

t( 15:17)

Question 18

What does IL 2 do

Answer 18

made by T CELL

Stimulates growth of T, B, NK, Mac cells

Question 19

A calcuim dependant adhesion molecule that binds epithilial cells together

Answer 19

Cadherin

Question 20

Defense Sublimation

Answer 20

Channeling impulse into a sociatly GOOD thiing

*Mature

Question 21

How does ligand binding to a TK receptor work

Answer 21

TK receptor dimerizes and exposes the active site

Question 22

Nasal septum perferation is probably

Answer 22

Substance Abuse most likely cocain mediated by vasoconstriction

Question 23

How long does an Acute Stress disorder go on for to start being called PTSD

Answer 23

ASD is over 3 days, less than 1 month

After 1 month, the symptoms are called PTSD

Question 24

Schizophrenic Symptoms lasting LESS than 6 months is called

Answer 24

Schizophreniform

Question 25

What are the 2 labs that evaluate a pleural effeusion (lights criteria)

Answer 25

Protein (high in exudate/ infection) LDH (high in transudate/ CHF)

Question 26

Primary Test for Herditary Spherocytosis

Answer 26

Osmotic fraglity Low OSM--> More hemolysis (vs control)

Question 27

Where does hemolysis in herditary spherocytosis occure

Answer 27

Spleen Spleen removal will lead to decreased bili gallstones, jaundice, and improved anemia

Question 28

Most likely maliganancy in Myasthenia Gravis

Answer 28

60-70% have hyperplstic thymic tissue 10-20% have Thymoma

Question 29

most likely malignancy for eaton Lamburg

Answer 29

Lung Cancer

Question 30

What kind of gene is RB

Answer 30

RB is tumor supressor Chromosome 13

Question 31

First line treatment for pheochromocytoma

Answer 31

Phenoxybenzamine - long acting alpha blocker Beta Blocker alone leads to HTN crisis

Question 32

If a premature baby has a brain bleed, what bleed is it

Answer 32

Germinal Matrix Hemmorrhag Germinal matrix is part of developing brain, involutes by week 28, very weak and bleds easily

Question 33

Amiodarone Drug Reactions

Answer 33

Class 3 K Blocker Hypo/Hyper- thyroid Photosensativity Pulm Fibrosis *P450 Inhibitor

Question 34

Why does Aspirin INtolerance Asthma happen

Answer 34

Dysregulation of Arachodonic Acid pathway Too much AA gets pushed down Leuktriene pathway instead --> Inflamation/asthma

Question 35

What happens to heart rate with nitrates

Answer 35

NItrates venodilate--> decrease preload--> reduces SV--> increases heart rate

Question 36

What does parathyroid hormone do

Answer 36

Increases serum calcium Decreases erum PO4

Question 37

This is the end organ resistance to PTH | AD condition with short stature and short fingers

Answer 37

Albright Osteodystrophy Labs show: Inc Phos, PHT Dec Ca

Question 38

What is Allelic Heterogeneity

Answer 38

Different Mutations IN THE SAME GENE leading to a similar phenotype

Question 39

What is Polygenic

Answer 39

Mutations at different genes leading to a similar phenotype

Question 40

In Maple Syrup Urine disease, what can pts not break down

Answer 40

Leucine Valine IsoLuecine (I Love Vermont maple syrup)

Question 41

What cell type makes androgen binding protein

Answer 41

Sertoli Helps maitain high testosterone for sperm making

Question 42

What receptor type does insulin use

Answer 42

Tyrosine Kinase

Question 43

What receptor does Glucagon and Epinephrine use

Answer 43

Gs

Question 44

If you have a PE, what will your PCO2 look like

Answer 44

PE--> V/Q mismatch--> Hypoxemia--> reflex HYPERventalation--> decreased CO2--> Resp Alk

Question 45

What kind of penetrance does neurofibromatosis have

Answer 45

100% Penetrance | Variable Expresivity

Question 46

Is red man syndrome from IgE

Answer 46

NO It is not an allergic side effcect Can be prevented by SLOWER infusion rate of vancomycin, which keeps blood histamine lower