Renal Flashcards
How do you calculate renal blood flow
Rbf= (renal plasma flow) / (1-hematocrite)
Where do thiazides act
early distal convoluted tubular
Name an osomtoic diruetic and where does it act
Manital
Proximal tube and descending loop
What does Lithium do to kidneys
Antags vasopressin on principal cells of the collecting duct
Leads to a nephrogenic DI
This presents with gross hematuria, acute flank pain, and passing of tissue in urine
Papillary necrosis
Seen in Sickle cell, DM, Analgegic, and Acute obstructive pylo
SAAD PAPa (with papillary necrosisi)
What is the triad of fanconi syndrome
Polyuria
Acidosiis
Hypophosphotemia
What is a “fanconi like” syndrome
Lead poisoning effect on the kidney
What is renal papillary necrosis
sloughing of necrotic renal papilla
Can be triggered byinfections
s/s: hematuria, protinuria
What are s/s of hypokalemia and how can a thiazide cause it
Muscle weakness, cramps, possible rhabdo
Thiazides–> Inhibit Na/Cl–> ↑ RAS–> aldosterone dumps H and K
What does ADH ↑ reabsorbtion of
Water
Urea
*reuptake of urea increases the concentration gradient to maximally concentrate urine
How do ACE inhibitors change GFR
They prevent efferent arteriole vasoconstriction (normally mediated by angiotensin)
VERY CONTRA-INDICATED in renal artery stenosis
How do you calculate filtration fraction
FF= GFR/RPF
What type of kidney disea is goodpasture
Type 2 Hypersense (Ab vs BM)
–> Rapidly progressive (crescentic) Glomerulonephritis
Nephritic
What kind of lung problem is in goodpasture
Restrictive
How is immunofluorescence on goodpasture kidney
Linear IgG on kidney/alveolar basement membrane
