Immunology Flashcards
Type 1 hypersensitivity
IgE
Basophils and mast cells response
ex: allergies
Type 2 hypersensitivity
IgG and IgM
Complement
PMN response
ex: Autoimmune hemolytic anemia
Type 3 hypersensitivity
Deposition of antibody- antigen complex
PMN response
ex: serum sickness
Type 4 hypersensitivity reaction
No humoral Component
T cell and Mac response
ex: contact dermatitis, TB skin test
Describe Acute hemolytic transfusion reaction
Given Blood
preformed ANTI- ABO ABs attack
Complement activates and lysis the blood and leads to shock
s/s: fever, hypotension, chest pain, back pain, hemoglobinuria
What do eosinophils do
IL5 (from Th2/masts) activates them during parasite infection
Parasite is coated in IgG/E that bind Eos Fc–> eos degranulation of major basic protein
How do eos act in a type 1 hypersensitivity
eos synthesize PGs, leukotrienes, cytokines that contribute to late phase type 1 hypersens
Eosin means
pink dye
Causes of eosinophilia
Neoplasia Asthma Allergic Chronic adrenal insuf Parasites
What is major basic protein
a helminthotoxin
What are the steps of Leukocyte Inflammatory accumulation
Margination Rolling Activation Tight adhesion and crawling Transmitigation
What mediates PMN rolling
L-Selectin on PMN
E-Selectin/P-selectin on Endothilial cells
How do PMNs do tight adhesion and crawling
CD18 beta 2 integrin binds ICAM-1 on endothilum
What mediates PMN Transmitigation
This is how PMN exits the blood via intigrin attachment to platlet endothelial cell adhesion molecule 1 (PECAM-1)
What recognizes a stop codon
releasing factor
