Onc/Heme

Question 1

This drug inhibits microtubules and the side effect is neurotoxicity

Answer 1

Vincristine

Question 2

This is seen in down syndrome
Has a rapid onset of symptoms
multiple cell lines are decreased

Answer 2

ALL (12:21) or (9:22)

B-ALL more common

Question 3

ALL stain

Answer 3

TDT

Question 4

Where does ALL like to met

Answer 4

CNS

teste

Question 5

Lead poisoining inhibits:

Answer 5

Delta- aminolevulinic acid dehydratase and ferrochelatase

*an early enzyme in the heme pathway

Question 6

Findings in lead poisoing

Answer 6

Microcytic anemia with basophilic stippling

s/s peripheral neuropathy
metaphyseal deposits of lead

Question 7

Lab findings in a lead poisoning

Answer 7

↑ ferritin (iron strorage)

↓ TIBC (less iron is in circulation)

Question 8

This vasculitis is associated with eosinophilia and p-anca

Answer 8

churg strause

Question 9

What gene has RB on it

Answer 9

13

Question 10

What is associated with 50% of hodgkin disease

Answer 10

EBV

Question 11

_______ is the most common lung cancer type

Answer 11

Adenocarcinoma

Question 12

Adenocarcinoma of the lung epidemiology

Answer 12

Happens in periphery of the lung

Usually women and NON smokers

Question 13

This is a tumor often seen near the knee. More frequent in women 20-40
oval or spindle shaped cells

Answer 13

Giant cell tumor

“double bubble, or bubble sign”

Question 14

What is characteristic of neurofibromatosis type 1

Answer 14

neurofibromas
cafe au late spots
Lish Nodules- spots on the eye

Question 15

What causes the problem in NF-1

Answer 15

loss of NF-1 tumor suppressor on chromosome 17

Question 16

What are all the things that can make G6PD hemolysis your blood

Answer 16

PAINS

Primaquine 
Aspirin/nsaids 
Ibuprofen 
Nitrofurantoin (antibiotic) 
Sulfonamide

Question 17

What is the inheritance of vWF deficiency

Answer 17

Autosomal Dominant

Question 18

What is missing in CGD

Answer 18

dysfx NADPH oxidase of monocyte

Question 19

When would you see increased lymphs with smudge cells

Answer 19

CLL

the smudge cells have a weak membrane and fall apart easily

Question 20

What has a 15:17 translocation

Answer 20

M3 type AML

Question 21

Define PICA

Answer 21

compulsive consumption of non food OR non staple food (like eating ice cream only) for over 1 month

Question 22

Who tends to get PICA

Answer 22

Pregos
School children
Results from iron deficiency anemia

Question 23

What do people with pica like to eat

Answer 23

Soil
Starch (like cornstarch)
Ice