Onc/Heme Flashcards
This drug inhibits microtubules and the side effect is neurotoxicity
Vincristine
This is seen in down syndrome
Has a rapid onset of symptoms
multiple cell lines are decreased
ALL (12:21) or (9:22)
B-ALL more common
ALL stain
TDT
Where does ALL like to met
CNS
teste
Lead poisoining inhibits:
Delta- aminolevulinic acid dehydratase and ferrochelatase
*an early enzyme in the heme pathway
Findings in lead poisoing
Microcytic anemia with basophilic stippling
s/s peripheral neuropathy
metaphyseal deposits of lead
Lab findings in a lead poisoning
↑ ferritin (iron strorage)
↓ TIBC (less iron is in circulation)
This vasculitis is associated with eosinophilia and p-anca
churg strause
What gene has RB on it
13
What is associated with 50% of hodgkin disease
EBV
_______ is the most common lung cancer type
Adenocarcinoma
Adenocarcinoma of the lung epidemiology
Happens in periphery of the lung
Usually women and NON smokers
This is a tumor often seen near the knee. More frequent in women 20-40
oval or spindle shaped cells
Giant cell tumor
“double bubble, or bubble sign”
What is characteristic of neurofibromatosis type 1
neurofibromas
cafe au late spots
Lish Nodules- spots on the eye
What causes the problem in NF-1
loss of NF-1 tumor suppressor on chromosome 17
What are all the things that can make G6PD hemolysis your blood
PAINS
Primaquine Aspirin/nsaids Ibuprofen Nitrofurantoin (antibiotic) Sulfonamide
What is the inheritance of vWF deficiency
Autosomal Dominant
What is missing in CGD
dysfx NADPH oxidase of monocyte
When would you see increased lymphs with smudge cells
CLL
the smudge cells have a weak membrane and fall apart easily
What has a 15:17 translocation
M3 type AML
Define PICA
compulsive consumption of non food OR non staple food (like eating ice cream only) for over 1 month
Who tends to get PICA
Pregos
School children
Results from iron deficiency anemia
What do people with pica like to eat
Soil
Starch (like cornstarch)
Ice
