Basic pharm

Question 1

How long does a 1st order kinetic drug take to reach stead state

Answer 1

These drugs reach stead state in 4-5 half lives

Question 2

What drugs do you avoid in elderly folks

Answer 2

Pretty much anything sedating

Beers criteria: 
1st gen antihistamine 
Tricyclics 
Sulfonylurea 
Alpha blocker

Question 3

What does first order kinetics mean

Answer 3

Fractional amount of drug eliminated per unit time

Question 4

How do you reverse atropine

Answer 4

Physostigmine

Question 5

In the case of rapid resolution to baseline from a drug (like thiopental)

Why does rapid resolution happen

Answer 5

Redistribution of drug

Drug rapidly leaves brain and goes to muscle

Thiopental is an anaesthetic

Question 6

An unpredictable rxn to a drug

Answer 6

Idosyncratic drug reaction

ex: G6PD

Question 7

an unpredictable specific drug reaction

Answer 7

Immunologic drug reaction aka allergy

You couldn’t know there was an allergy (unpredictable) but you did know the reaction (allergy)

Types 1-4 hypersensitivities

Question 8

a predictable drug reaction at a dose lower than expected

Answer 8

Exaggerated sensitivity