Rheum

Question 1

What do intigrins do

Answer 1

Enable leuks to exit blood stream
Absent in leukocyte deficiency–
Will have delayed umbilical cord detachment

Question 2

What is the main function if PTH

Answer 2

Increase bone reabsorbtion aka increase ca

Phosphate is decreased in serum (put out in urine)

Question 3

What does pth act on

Answer 3

Osteoblasts, which increase rank, which matures osteoclasts

Question 4

What can block rank and why do you care

Answer 4

Osteoprogesterin blocks rank

When estrogen gets low, osteoprogesterin gets low, clasts over activate, and…

OSTEOPOROSIS occurs

Question 5

Gram negative oxidase positive rod causing itchy rash

Answer 5

Psuedmona

Hot tub folliculitis

Question 6

Blue black deposits on sclera and ear with joint pain

Answer 6

Alkaptonuria

Also urine turns black in the sun

Question 7

What does fibrillin do

Answer 7

Glycoprotein scaffold for elastin

Question 8

What are the typical lab values for osteoporosis

Answer 8

Totally normal ca, phos, and PTH

Question 9

What mediates muscle tone in nervous system

Answer 9

Golgi tendon organ

Question 10

What is linked to drug induced lupus

Answer 10

Drugs metabolized by acetylation

Ex: INH

Question 11

Rhomboid crystals with knee pain

Answer 11

Psueodo gout

Crystal made up of calcium pyro phosphate w/ + bifringence

Question 12

What is the first line treatment for gout

Answer 12

NSAID

Question 13

What drug do you NOT give DURING a gout attack

Answer 13

Uric acid lowering drugs

Ex: xanthine oxidase inhibitor

These PREVENT gout but make active gout worse

Question 14

What do gout needles look like?

Answer 14

Needle shaped

Negative bifringence

Question 15

Remembering the contraction of muscle bands

Answer 15

HIZ shrinkage (these shorten)

A band is Always the same length

Question 16

Problems with umbilical cord detachment and recurrent skin infections w/I puss

Answer 16

Leukocyte adhesion deficiency
AR
No CD18 , no intigrins

Question 17

What is the MOST important factor for osteoporosis

Answer 17

Genetics

Question 18

Proximal muscle weakness

Over expression MHC 1 on sacrolema

Answer 18

Polymyositis

Cd8 infiltration leads to myocyte damage

Question 19

This auto antibody is the most specific for RA

Answer 19

Citralunated peptide

Question 20

A patient with cancer and high serum calcium likely has what elevated?

Answer 20

Parathyroid hormone related protein.

Question 21

Reparative kneeling may lead to what?

Answer 21

Pre patellar bursa

Question 22

What allows the binding of myosin to actin?

Answer 22

Calcium binding to troponin c

Question 23

inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect. This has proven useful in the treatment of acute gout flares.

Answer 23

Colchacine

Question 24

What biopsy is characteristic of polyarteritis nodosa

Answer 24

Multisystem involvement with biopsy showing transmural inflammation of arterial walls with fibrinoid necrosis.

Small and medium vessels.

Question 25

Do psgn and acute rhematic fever usually happen together

Answer 25

No. If arf is present, most likely the complication will be pancarditis Mitral stenosis occurs years after original illness

Question 26

Define Parkinson's cogwheel rigidity

Answer 26

Passive movement has ratchet like resistance

Question 27

Joint problems that arise with a myloprofilferative disorder (ie polycythemia vera)

Answer 27

Gout Myloprofilferative disorder has increased irate production

Question 28

What is seen in mitochondrial myopiathies

Answer 28

Red ragged fibers

Question 29

What is a first line treatment for RA

Answer 29

Methotrexate

Question 30

What are pth levels like in sarcoidosis

Answer 30

Low Sarcoidosis has vit d activation by macs which increases ca absorption

Question 31

What medicine is structurally similar to pyrophosphate

Answer 31

Bisphosphonate

Question 32

Half of the patients with lambert eaton also have this?

Answer 32

Malignancy | Classically small cell carcinoma

Question 33

What muscle controls external shoulder rotation in the cuff

Answer 33

Infraspinatus

Question 34

Classic autoantibody in polymyositis

Answer 34

Anti jo 1 antibody is directed against the histidyl-tRNA synthetase Anti nuclear (very easy to confuse with SLE)

Question 35

Does an LP help you determine if there is osteomyolitis

Answer 35

No | Get an MRI

Question 36

The suffix cept for Rx will clue you in for

Answer 36

A receptor molecule

Question 37

The nib in a drug name clues you in for

Answer 37

Kinase inhibitor

Question 38

Anti mitochondria antibody indicates

Answer 38

Primary biliary sclerosis

Question 39

Anti cyclic citrulated antibody is

Answer 39

RA

Question 40

Lab finding for ACTIVE SLE attack

Answer 40

Reduced complement (due to immune complex deposition in organs) Also weirdly they can have a hard palate ulcer

Question 41

Define a contracture

Answer 41

a condition of shortening and hardening of muscles, tendons, or other tissue, often leading to deformity and rigidity of joints. Excess matrix metaloproteins

Question 42

What is a t tube

Answer 42

Part of sarcolema | Allows cordoninated contraction

Question 43

What kind of signaling does RANK do

Answer 43

Rank signals NFKB to osteoclasts precursor

Question 44

What is succinylcholine

Answer 44

Fast acting depolerizing Neuromusclual block

Question 45

What kind of block is pancuronium

Answer 45

Non depolerizing block.

Question 46

How do you reverse a nondepolerizing NMH block

Answer 46

Neostigmine

Question 47

Examination showing tenderness in snuff box

Answer 47

Scaphoid fx Risk of a vascular necrosis

Question 48

Why bone problems do ppis lead to

Answer 48

Ppi decreases stomach acid Calcium doesn't absorb Osteoporosis may occure

Question 49

Will the medial lymph system of the leg drain to the popliteal

Answer 49

No. Medial runs from medial foot to superficial inguinal nodes

Question 50

Where would a lesion be if popliteal and superficial inguinal lymphs are big

Answer 50

Lateral leg

Question 51

Having a rash + muscle weakness is

Answer 51

Dermatomyositis

Question 52

What is the other name for churge straus + what s/s

Answer 52

Eosinophilic Granulomatis with polyangitis Late onset asthma** Other "allergy" type stuff Medium sized vasculitis Panca (ab vs pmn myeloperoxidase)

Question 53

Osteoporosis can be promoted by what simple drug class

Answer 53

Glucocorticoid | Also ppi

Question 54

Abusing anabolic steroids might lead to this skin finding

Answer 54

Acne

Question 55

What is etanercept a decoy for

Answer 55

Tnf a

Question 56

Diffuse muscle pain ontop of giant cell arteritis is known as

Answer 56

Polymyalgia rhematica

Question 57

Which nerve is anterior and lateral on the elbow

Answer 57

Radial

Question 58

What nerve is anterior and medial on the elbow

Answer 58

Median

Question 59

If RA were to affect the spine, which region would it be

Answer 59

Cervical

Question 60

b/c of PUD, a gout pt cannot use NSAID as first line rx. Now what?

Answer 60

colchicine | inhibits microtubule polymerization

Question 61

Besides your abs, what m helps you go from supine to sitting w/o using hands

Answer 61

Psoas major

Question 62

What ligament is damaged in nursemaids elbow

Answer 62

Annular ligament | nursemaid= radial head subluxation

Question 63

What is the halmark of rickets histology

Answer 63

increase in unmineralized osteoid matrix

Question 64

What is the primary vessel messed up for femoral head osteonecrosis

Answer 64

medial circulflex

Question 65

What is Denosumab

Answer 65

RANK L inhibitor