General sciences Flashcards
What does lead directly inhibit
delta aminolevulinic acid
Ferrochelatase
S/s: neurotoxicity, anemia, and ZN in place of FE I’m portoporferin
What is the function of IL 10
Inhibits th1
Reduced mhc2
Suppresses apcs
This helps package DNA up tightly without joining the histone core
H1
Other Hs are wrapped up in DNA
What makes major basic protein
Eos
Is the immune response to helmiths
What do basophils contain
Granules
-Heparin
-Histamine
Leukotrienes made on demand
What do basophils do
mediate allergic reaction
any of a group of biologically active compounds, originally isolated from leukocytes. They are metabolites of arachidonic acid, containing three conjugated double bonds.
Leukotriene
This drug is for the cray crays and is the only partial D2 agonist
Aripiprazole
atypical antipsychotic
What on ENDOTHELIAL cells allows for chemotaxis
Intercellular adhesion molecule 1
Integrin
membrane proteins that maintain
integrity of basolateral membrane by binding
to collagen and laminin in basement membrane
Integrin
What does a prostacyclin do
↓ platelet aggregation
↓ vascular tone
Periodic acid–Schiff stains?
Gycogen
PaS the sugar
Kidney– annoying stuff that happens to kids
PSGN- nephritic
Minimal change disease
What is the function of a proteasome
Degraded proteins
Can degrade viral proteins to express on MHC 1
What does a lysosome do
Organelle containing acid
Degrades fatty acid, protein, nucleic acid, and carbs
Dysfunction of lysosome is called
Mucopolysaccharidoses
When does a ribosome attach to the ER
when the protein it is making is meant for secretion, membranes, etc
ribosome will not go to ER if the protein is meant to stay in the cytosol
What is an enhancer (genetics)
Helps increase gene activity
can be located kinda anywhere
NOT a promoter which is 25-75 upstream
What is the opposite of an enhancer
a silencer
What is GPCR
A large family of 7 transmembrane domaine receptors that activate intracellular 2nd messenger systems
2 pathways: cAMP signalling, and Phosphatidly signalling
What happens if you activate Gq a subunit
Phophatidylinositol pathway
Gq a–> activates Phospholipase C–> degraded lipid membranes into DAG and IP3
DAG–> activates Protiein Kinase C
IP3–> releases Ca
During catabolism of protein into glutamate (to ultimately make glucose), amino groups are transferred to
a-ketoglutamate
Ultimately, what is the end result of the Jak/STAT path
JAK activates the cytoplasmic transcription factor STAT to promote gene transcription
Therefor, growth stuff tends to use this path (GH, Epo, etc)
What tissues predominatliy make alkaline phosphotase
Bone and Liver
hepatic y- glatamyl transpeptidase test is not in bone, and helps tell disease between bone and liver apart (if alk phos is elevate)
