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What is raltegravir
integrase inhibitor vs HIV
How does vancomycin work
directly inhibits peptidoglycan synthesis
In ATN when do you have fluid overload
maintenance stage
↓ UA output
In ATN, what electrolyte problems do you have/ when
Happens in recovery phase
hypokalemia- most serious issue
Hypocalcemia
What muscle symptom can hypothyroid present with
↑ CK levels is common presenting symptom
myalgia
proximal muscle weakness
cramping
myoedema
What is a major side effect of protease inhibitors in HIV therapy
Hyperglycemia
drugs end in “Navir”
Where is most water in kidney absorbed
PCT
Can compress anterior cerebral artery.
Cingulate (subfalcine) herniation under
falx cerebri
Duret
hemorrhages. Usually fatal.
Downward transtentorial (central) herniation- caudal displacement of brainstem
uncal herniation
Uncus Compresses ipsilateral CN III (blown pupil, “down-and out” gaze)
Cerebellar tonsillar herniation into the foramen magnum outcome
coma and death if brainstem compressed
What is GLUT
carrier molecule to get glu into cell
Need to treat osteoporosis, DM, and htn, use this
thiazide
A dry bone marrow tap might be
hairy cell leukemia
middle aged peeps, bone marrow failure, splenomegally
Generally, how do fibrates work
↓ VLDL
describe biliary atresia
progressive obstruction of bile ducts
s/s: jaundice, dark urine, hyperbilirubinemia in baba
surgery a must or death in 2 years
You cannot tell this apart from viral hepatitis and it will kill you in days
fulminant hep from inhaled anesthetics
what does glycerol kinase do
glycerol from tri-gly –> glucose in liver
What is the first step in FA synthesis
acetyl coa carboxylase
acetyl coa–> malonyl coa
what kind of diverticulum is zenker
false
whats most important for colon ca in UC
duration and extent of the disease
usually multifocal with anearly p53 mutation
a confidence interval of 95% is a p value of
0.05
a confidence interval of 99% is a p value of
0.01
in the leg whats most common site of compartment syndrome
Anterior compartment ‘
houses deep peroneal n, and anterior tibial a and v and foot extensors
How long can glycogenolysis last you
12-24 hours
this thing is in the TCA cycle. But it can leave to go help with gluconeogenesis. what is it?
Oxaloacetate via phosphoenolpyruvate carboxykinase