Tumour Immunology Flashcards
Name two types of cancers we can inherit
- Transformation of germline cells (INHERITABLE CANCERS)
2. Transformation of somatic cells (NON-INHERITABLE CANCERS)
Which are more common, non-inheritable or inheritable cancers
Non-inheritable - 90% of all cancers
What cancer do UV contribute to
Skin
What cancer do chemicals contribute to
Lung
What cancer to HPV cause
Cervical
What cancer do helicobacter cause
stomach cancer
Why do cancers continue to grow
- Evade apoptosis
- Ignore anti-proliferative signals
- Limitless replication potential
- Sustained angiogenesis
- Escape immune surveillance
What is the ultimate goal of tumour immunology
Induce clinical effective anti-tumour immune responses that would discriminate between tumour cells and normal cells in cancer patients
What is cancer immunosurveillance
Immune system can recognise and destroy newly transformed neoplastic cells
What is cancer immunoediting
Tumours tend to be genetically unstable and so the system can kill and induce changes in the tumour resulting in tumour scape and recurrence
What are TSAs
Peptides on the surface of tumour cells
Where are TSAs (Tumour-specific antigens) found
Only on tumours
How do Tumour Specific Antigens form
Point mutations or gene rearrangement
Where are TSAs derived from
Viral antigens
Where are Tumour Associated Antigens found
On both normal and tumour cells
