Cardiovascular Pharmacology Flashcards
When is ANP and BNP released by the atria and ventricles
Stretching of walls
Increased pressure
Overload
What does ANP and BNP do in the body
Increase renal excretion of water and sodium
Vasodilation
What enzyme metabolises ANP and BNP
Neutral endopeptidases (inhibit these and this will increase plasma BNP and ANP levels - good for pharmacological study!)
When are nitrates given
Angina
Heart Failure
GTN
Adverse effects of nitrates
Headaches
First-line treatment for angina
Beta-blocker or calcium-channel blocker
What else is given for angina control
Aspirin + clopidogrel
Statins
GTN for acute attack
Anti platelet therapy for ACS
Aspirin + Clopidogrel
Antithrombin therapy for ACS
Fondaparinux
High risk cases for ACS medications
IIb/IIIa inhibitors
What are Class IV drugs
Calcium channel blockers
Amiodarone adverse effects
QT prolongation
Ventricular tachycardia
Hypothyroidism
Optic neuropathy
