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Arterial and Venous thrombosis Flashcards

1
Q

What is the difference between a clot in a living and a dead person + why

A

Living - one layer
Dead - red cells tend to settle out before clot forms so we have two layers: Lower deep-red and upper clearer with platelets

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2
Q

What does the clot in a dead person take the shape of

A

The shape of the vessel in which they have formed

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3
Q

How does the clot formed in a dead person break down

A

Hydrolysis by enzymes released by cells of the vessel wall and RBCs

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4
Q

What is a thrombus

A

Solidification of blood contents that form within the vascular system during life

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5
Q

What is the role of a platelet

A

Closing small gaps in vessel walls through trauma

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6
Q

What are platelets derived from

A

Megakaryocytes

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7
Q

What structures can be found in platelets

A
  1. Mitochondria
  2. Cytoskeleton
  3. Alpha granules
  4. Dense granules
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8
Q

What do alpha granules in platelets contain

A

Fibrinogen, Fibronectin, Platelet growth factor and anti heparin

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9
Q

What are found in dense granules of platelets

A

ATP and ADP

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10
Q

Role of ATP and ADP in clotting

A

Platelet aggregation

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11
Q

What is the result of the platelet cascade forming in an intact non-damaged vessel

A

Thrombus

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12
Q

What three ways can a thrombus form

A
  1. Changes in intimal surface of vessel
  2. Changes in pattern of blood flow
  3. Changes in blood constituents
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13
Q

What three ways can a thrombus form

A
  1. Changes in intimal surface of vessel
  2. Changes in pattern of blood flow
  3. Changes in blood constituents

^ Virchow’s triad

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14
Q

How does an atheromatous plaque cause arterial thrombosis

A
  1. Plaque enlarges
  2. Plaque protrudes into lumen
  3. Disrupts blood flow.
  4. Causes loss of intimal cells
  5. Denuded plaque surface is presented to platelets
  6. Causes fibrin deposition and platelet clumping
  7. Bare luminal surface of vessel will have exposed collagen and platelets
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15
Q

How does an atheromatous plaque cause arterial thrombosis

A
  1. Plaque enlarges
  2. Plaque protrudes into lumen
  3. Disrupts blood flow.
  4. Causes loss of intimal cells
  5. Denuded plaque surface is presented to platelets
  6. Causes fibrin deposition and platelet clumping
  7. Bare luminal surface of vessel will have exposed as endothelial cells lining vessel are damaged to collagen and platelets
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16
Q

What two of the three Virchow’s triad can apply to arterial thrombosis and under what conditions

A
  1. 3rd - Plaque is in aorta of the smoker or someone with high cholesterol / LPL as there is a change in blood constituents
    (book didn’t mention the other one lol)
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17
Q

Why is arterial thrombosis in the aorta of a smoker / high LPL self-perpetuating

A

Platelet growth factor contained in alpha granules causes proliferation of arterial smooth muscle cells

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18
Q

What do atheromatous plaque mostly consist of

A

Arterial smooth muscle cells

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19
Q

What is the first layer of a thrombus made of

A

Platelets

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20
Q

What is and how does the second layer of a thrombus develop

A
  1. Red blood cells

2. Precipitation of fibrin meshwork traps red blood cells above platelet layer

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21
Q

What is the alternating layer of a thrombus called

A

Lines of Zahn

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22
Q

In which direction will the thrombus grow in

A

Direction of the blood flow - propagation

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23
Q

Why does an atheroma not occur in veins

A

Low pressure

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24
Q

How does venous thrombosis occur

A
  1. Presence of valves causing disturbances or exposed to trauma
    2
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25
How do venous thrombosis occur
1. Blood pressure falls during surgery or heart attack slowing blood flow 2. Venous return slows down due to lack of calf muscle contractions (DEEP VEIN THROMBOSIS)
26
What symptoms would I be looking for in people with arterial thrombosis
1. Loss of pulse distal to thrombus | 2. Signs of impaired blood supply (cold, ,pain and pale in area)
27
What symptoms would I be looking for in individuals with venous thromboses
Area becomes swollen, tender and red as blood is still being taken to site but not drained by veins.
28
Why is the site tender during vein thromboses
Because ischaemia is developing in vein wall
29
How do myocardial infarctions result in a death
Thrombus formation in coronary arteries
30
How does a thrombus lead to a stroke
Forms in cerebral vessel
31
What three things can happen to a thrombus
1. Resolve 2. Organised into scar by macrophages (clear thrombus) and fibroblasts (collagen) 3. Intimal cells of vessel proliferate and capillaries grow into thrombus, recanalising the occlusion 4. Death (occludes vital organ) 5. Embolism
32
What is an embolism
Mass material in circulatory system that can get lodged in vessel and block lumen
33
How are most embolisms caused
By thrombus
34
Where do most venous thromboses form
Leg veins (95%) / pelvic veins / Intracranial sinuses
35
How does a pulmonary embolism form
Thromboses from areas where a venous thromboses has occurred will enter pulmonary system
36
Can an organised thrombus cause a pulmonary embolism
Yes but it is not severe if the thrombus is small but these are permanent and may cause small respiratory deficiency
37
Can an organised thrombus become severe
Yes, due to an accumulation of small, organised thrombus forming in long-term
38
What is an accumulation of tiny embolic events in the pulmonary system going to lead to
Damage - idiopathic pulmonary hypertension
39
What is the result of 2nd class embolisms in the pulmonary system
Acute respiratory and cardiac problems
40
What are the symptoms of 2nd class pulmonary embolisms
Chest pain | Shortness of breath
41
Why can a pulmonary embolism cause shortness of breath
Occluded vessel supplying lung infarcting the area
42
What is the long-term effect of 2nd class pulmonary embolisms
Recurrent episodes even if most people recover and lung function is impaired
43
What do 3rd class pulmonary embolisms result in
death
44
Where do 3rd class pulmonary embolisms come from
Leg veins (have same shape as the vessels they arose from)
45
Where are thrombi in 3rd class embolisms found
At bifurcation of a major pulmonary artery
46
Where do systemic embolisms arise from
Arterial system (heart or atheromatous plaque)
47
Where may a thrombi form in the heart
Areas of cardiac muscle that have died due to myocardial infarction
48
How would a thrombi form in the heart
Loss of normal endothelial lining and exposure of underlying collagen to platelets Dead myocardium disrupts blood flow
49
What condition may cause thrombosis within the heart
fibrillation
50
How does atrial fibrillation cause a thrombi to form
stagnates blood in atrial appendages, when heart rhythm normalises, fragment breaks off
51
In what chamber of the heart to emboli originate from
left atrium or left ventricle
52
What is the consequence of the emboli originating from the left ventricle and atrium
Can travel to anywhere in the systemic circulation (e.g. brain vessels)
53
Where may a large emboli from the heart lodge at
bifurcation of aorta cutting supply to lower or upper limbs (needs quick diagnosis before it can't be reversed)
54
What is the effect of smaller emboli
1. lodge in peripheral vessels | 2. Cause gangrene in fingers
55
What drug stops platelet aggregation
Aspirin
56
Define infarction
reduction in blood flow and subsequent death of cells
57
What is the impact of a small emboli travelling to the kidney
It asymptomatic Causes death in area distal to site of impaction
58
What is the result of an emboli travelling to the intestines
Death of whole sections of bowel due to superior mesenteric artery block
59
What is an embolic atheroma
Fragments of atheromatic plaque embossing in the lower limbs (e.g. causing ischaemic toes)
60
What is a platelet emboli
Platelet deposition in early stages of atheroma formation can break off
61
Are platelet emboli dangerous
No unless they enter the brain vessels = TIA
62
What are fat embolisms
Severe trauma to long bones causes fat from marrow to release into circulatory systems.
63
What are gas embolisms
When we go from high-to-low pressure environments Nitrogen bubbles form during decompression and enter bones/joints (pain)
64
What is an amniotic embolism
During labour, increased pressures in the uterus causes amniotic fluid to travel into the circulation and LODGE into the lungs (pulmonary embolism)
65
What is a tumour embolism
Tumour fragments break off (not a big deal)

Year 2 (155 decks)

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