Infective Endocarditis Flashcards

1
Q

What is infective Endocarditis

A

Infection of heart valves and other endocardial lined structures within the heart

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2
Q

How do people catch infective endocarditis

A
  1. Regurgitant or prosthetic valves infected

2. Introduce infectious material into the blood stream or directly onto the heart during surgery

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3
Q

Clinical presentation of infective endocarditis

A
  1. Depends on site
  2. Signs of systemic infection (fever, sweats)
  3. Embolisation (stroke, bone infections, MI)
  4. Valve dysfunction (heart failure, arrhythmias)
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4
Q

What is the modified Dukes Criterion for diagnosis

A

2 Major:

  1. Bugs grown from blood cultures
  2. Evidence of endocarditis on echo or new valve leaks

5 Minor:

  1. Predisposing factors
  2. Fever
  3. Vascular Phenomena
  4. Immune Phenomena
  5. Equivocal blood cultures

Definite: 2 major, 1 major + 3 minor, 5 minors

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5
Q

Pros of Transthoracic echo

A

Safe, non invasive

no discomfort

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6
Q

Cons of TTE

A

Poor images so lower sensitivity

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7
Q

Transoesophageal Echo pros

A

Clearer pictures

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8
Q

Cons of Transoesophageal echo

A

Tube pushed down throat

Risk of perforation or aspiration

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9
Q

What is peripheral stigmata

A

Splinter haemorrhages

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10
Q

What are sober nodes

A

Tender nodules in the digits of a patient

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11
Q

What are laneway lesions

A

Haemorrhages and nodules in the fingers of patients with infective endocarditis

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12
Q

Characteristics of streptococci that cause infective endocarditis

A

Gram positive cocci in chains

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13
Q

How do we identify Strep. viridian’s

A

Optochin resistant

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14
Q

Types of colony made by strep. viridian’s

A

Alpha-haemolytic colonies

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15
Q

Characteristics of Staphylococci that cause infective endocarditis

A

Gram positive
Cocci
clusters

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16
Q

What test is performed on the Staphylococci being cultured overnight

A
  1. Coagulase test - shows a positive result for staph. aureus
17
Q

How should staph. aureus respond to cefoxitin and penicillin

A

Resistance

18
Q

How should staph. aureus respond to vancomycin

A

Sensitivity

19
Q

What antibiotic is staph. aureus resistant to

A

cefoxitin - change to vancomycin

20
Q

What test is performed to confirm staphylococcus is present

A

Coagulase test

Negative - staphylococcus