Treponema Pallidum-Pallidum Observatory Flashcards
What is the result of gram staining Treponema Palladium
No result because a spirochete
What culture is Treponema Palladum grown on
Can not be cultured, only grown in rabbit testes
What disease is caused by Treponema Palladum
Syphalis
How is Treponema Palladum transmitted
STI
What is required for the visualization of Treponema Palladum
Dark field microscopy
What are the two forms of screening for Treponema Palladum
VDRL
RPR (rapid plasmin reagent)
Both are very non specific
What is the confirmatory test run for Treponema Palladum
Looking for FTA antibodies
What are the clinical presentations of stage 1 of Treponema Palladum infection
Painless genital chancre (due to invasion of small blood vessels, where necrosis kills nerves)
What is state two of infection with Treponema Palladum
Systemic portion with a maculopapular rash on the palms and soles of the feet.
-Formation of condoloma lata (bumps that are flat topped)
What are the clinical presentations of stage 3 of infection with Treponema Palladum
- Gumma formation (tissue growth with firm necrosis center)
- Aortitis (aka treebarking as bloodvessels supplying aorta die)
- Loss of dorsal columns
- Argyle Robertson syndrome
Which conditions will cause aortitis and treebarking
Treponema Palladum
What occurs ith loss of dorsal columns in Treponema Palladum
Loss of proprioception pain and touch
What is Argyle Robertson syndrome and what causes it
Caused by Treponema Palladum
-Pupils will accommodate for distance but not for light
What are the clinical presentations of congentical Treponema Palladum
- Saber shins (forward bending tibia)
- Saddle shaped nose
- Hutchinson’s teeth (notched incisors)
- Mulberry molars (outgrowing enamel off teeth)
- Deafness
What is the treatment for Treponema Palladum
Penicillin
What is Jarish Herschimer reaction and what is the cause
With treatment of spirochetes, they die, causing release of cytokines that make people feel sick with fever and chills
