Ebstein-Barr Virus: Ye Olde Epstein Bar Flashcards
What is the nucleic acid of EBV
Double stranded DNA virus
What illness does EBV cause
Mononucleosis
How is EBV spread
Via mouth secretions, usually thought kissing (aka kissing disease)
What are the clinical symptoms of EBV infection
Fever
Splenomegaly
Tender lymphadenopathy in posterior cervical (can also get just general)
Pharyngitis
What are the immune cells usually fighting EBV
CD8 Cytotoxic T cells
What are the characteristics of the T cells that are fighting the EBV infection
Reactive lymphocytoses, which show as downy cells, which are atypical CD8 cells that have a large cytoplasm with oval or folded nucleus under microscopy
Where is the location of EBV during a non outbreak
Latent in B cells
What is the host cell target and how does EBV enter
B cells are the target and get in the CD21
What is commonly seen in EBV patients with regards to pharyngitis
Production of white pus from the throat
What is the most reliable way to differentiate between EBV pharyngitis and step
EBV is present in late teens to adults, which strep is more common in children
What occurs if EBV is misdiagnosis with strep and given amoxicillin or ampicillin
Develops a maculopapular rash (red spots)
What are the three forms of cancer that are associated with EBV
- Hodgkin’s lymphoma with mixed cellularity
- Nonhodgkin’s lymphoma, Burkitt’s lymphoma
- Nasopharyngeal carcinoma
What are the chacteristics of the B cell lymphoma in weakened immune systems in those with EBV
Hodgkin’s lymphoma with mixed cellularity, which contain the Reed-stern cells
What is the characteristic of the Nonhodgkin’s lymphoma in those with EBV
Burkett lymphoma, which leads to the large jaw lesion and swelling
What is the most common translocation of Burkitt’s lymphoma
T8:14
Which population is nasopharyngeal cancers as a result of EBV is at a higher risk
Asian
IN those with HIV and have EBV, what is the common clinical presentation seen
Oral Hairy Leukoplakia, which is not precancerous
What is the diagnostic tool used to diagnosis EBV
Monospot antibody test
What is the monospot antibody test looking for in EBV infection
The production of heterophile sheep antibodies that agglutinate
In patients with EBV, what is the main thing they should avoid
Because of splenomegaly, they should avoid contact sports because the increased risk of splenic rupture
What is the state of envelope in EBV
Viral envelope is present
