Legionella-SS Cystein Joins The Legion Flashcards
What is the result of gram staining of Legionella
Gram Negative
How is Legionella visualized by staining
Although it is gram negative, it will only weakly stain. Must use silver stain to visualize
Which agar is used to grow Legionella
Charcoal yeast extract with cysteine and iron
What are the two illnesses caused by Legionella
- Pontiacs disease
- Legionella disease
What are the clinical presentations of Pontiacs disease
Caused by Legionella
-Fever and malaise
What is the clinical presentation of Legionnaires disease
Caused by Legionella
- Hyponutremia
- atypical pneumonia
- High fever >104
- Headache and neuro symptoms
- Diarrhea
How would Legionella present on an X-RAY
Atypical Pneumonia with patchy Unilateral infiltrate
What group of patients is at higher risk for Legionaires
Smokers and elderly men
What would be the stem that would lead to Legionella as the main thought
- Smoker, older male
- Hyponatremia (,130)
- Confusion and headache
- Diarrhea
What is the lab test run to confirm Legionella
Rapid antigen urine test
What are the treatments for Legionella
Flouroquinolone (preferred), macrolides
What is the state of oxidase in Legionella
Oxidase positive
What is the main virulence factor of Legionella
Zinc metalooprotease, which is Cytotoxic, inhibits PMN production and superoxide production.
-Deactivates IL1, CD4 and TNF
