Mycobacterium Leprae-Good, Bad, And Lion Faced Flashcards
What is the result of gram stain with Mycobacterium Leprae
No result since it is acid fast
What does Mycobacterium Leprae have to be stained with
Acid fast aka carbol fusion stain
What is the significance of the type of temperature preferred by Mycobacterium Leprae
Prefers cold environments, so preferred invasion of the extremities where it is cooler
What is the major reservoir for Mycobacterium Leprae
Armadillo
What is another term for Mycobacterium Leprae infection/disease
Hansons disease
What are the type of conditions caused by Mycobacterium Leprae
1-Tuberculoid
2-Lepromatous
What is the type of immune response seen in tuberloid form of Mycobacterium Leprae
TH1 aka cell mediated
How is the TH1 involved in the tuberculoid form of Mycobacterium Leprae infection
Macrophages engulf the bacteria and are able to contain the bacteria
What is the method of testing for tuberculoid form of Mycobacterium Leprae
Skin test for immune reaction, which is similar to the TB test
What would a biopsy of tuberculoid lesions in Mycobacterium Leprae infections contain
Only a small amount of bacteria
What would a biopsy of lepromatous form of Mycobacterium Leprae contain
Large amounts of bacteria
What are the characteristics of the lesions seen in the tuberculoid form of Mycobacterium Leprae
Well demarcated hairless lesions on the skin
What is the cell type involved in the immune response to lepromatous form of Mycobacterium Leprae
TH2, aka humoral response
What is the mechanism causing the lepromatous form of Mycobacterium Leprae
Weak TH1 response, where the macrophages are unable to contain the infection
What is the method of transmission of lepromatous form of Mycobacterium Leprae
Human to human transmission
What are the areas that the lepromatous form of Mycobacterium Leprae test to show lesions
- The hands and feet due to the cooler environment
- Extensor regions
What are the characteristics of the lesions in the lepromatous form of Mycobacterium Leprae
Well demarcated lesions
What is the diagnostic feature seen in patients with lepromatous form of Mycobacterium Leprae
Leonine facies, which is basically facial deformities
-Loss of eyebrows and eyelids, loss of nose, ear nodules
What is diagnosis of a patient that presents with loss of eyebrow, eyelids, ear nodules, nose loss, almost looking like leonine
Mycobacterium Leprae as lepromatous form
What is the treatment of tuberculoid form of Mycobacterium Leprae
Dapsone and rifampin for 6 months
What is the treatment for lepromatous form of Mycobacterium Leprae
Dapsone, rifamptin and clofazimine for 2-5 years
