Rhabdovirus-Rabid Wrecking Yard Flashcards
What is the sense and nucleic acid of Rhabdovirus
Negative Sense strand RNA virus
What is the state of the envelope in Rhabdovirus
Viral envelope is present
Histologically, what does the capsule of the Rhabdovirus look like
Bullets
What is the morphological characteristic of the viral capsule in Rhabdovirus
Helical shaped
What is the method of transmission for Rhabdovirus
Zoonotic virus, so commonly in animals such as dogs, squirrels, foxes, which is then transferred to humans
What is the number 1 transmitter of Rhabdovirus
Bats
What is the location of replication and entry for the Rhabdovirus
Glycoprotein binds to the nAchR on the post synaptic side of the NMJ, where it will then replicate
What does the Rhabdovirus cause
Rabies
What is the process of infection with Rhabdovirus
Infects the NMJ, then travels in the retrograde motion in the peripheral nerves to the dorsal roots. It will then travel to the brain
What are the general clinical symptoms seen in Rhabdovirus
Tingling, increased salivary production, muscle spasms, throat/larynx spasms, dysphasia, encephalopathy, fever
What is the method of diagnosis for Rhabdovirus
Neri bodies, which are eosinophilic inclusions
Where are Neri bodies found in Rhabdovirus
- Pyramidal cells in the hippocampus
- perkiness cells
- Cerebellum
What is given to patients who are bitten and suspected to have Rhabdovirus
Passive immunization with IgG prior to symptoms to kill the virus
What is given to patients who are not evensuspected to have been bitten
Killed vaccine
