Shigella-She Gorilla's Circus Flashcards
What is the result of gram stain with Shigella
Gram negative
What is the main clinical presentation of Shigella
Gastroenteritis, with bloody diarrhea
What is the result of plating Shigella on hektoin agar
Forms green colonies
How can shigella be differentiated from salmonella
Shigella grow green on hektoin agar while salmonella grown black
What is the state of sulfer in Shigella
H2S negative
What is the characteristic of motility in Shigella
Nonmotile
What type of secretion does Shigella use
Type 3
What is the characteristic of acid stability and how does this affect infection
Acid stable, so it requires fewer organisms to infect
What cells are infected by Shigella and what is the mechanism
M cells, where they are engulfed, then escape the phagolysosomes
How does Shigella propel itself from cell to cell
Actin tail, similar to the one seen in Listeria
What is the location of replication in Shigella
Facilitative intracellular
What is the condition seen in children less than 10 with infection of Shigella
Hemolytic uremic syndrome
What is the process of hemolytic uremic syndrome and what is the organism that causes it
Caused by Shigella dysenteria
- Drop in platelet and hemolytic
- Progerminal diarrhea
- Followed by acute renal failure and glomerular damage
What is commonly seen in children with hemolytic uremic syndrome
Formation of shistocytes as the RBCs are ripped
What is the mechanism of action of the Shigatoxin
Binds to 60s ribosome and prevents translation
What is the treatment for Shigella
Macrolides and fluoroquinolone
