HSV 1 And 2-Hermes Flashcards
What is the nucleic acid for HSV1 and 2
Linear, Double stranded DNA
What are the viruses in the TORCHES infections
- TOxoplasmosis
- Rubella
- CMV
- Herpes
- Syphalis
What is the state of envelope in HSV 1 and 2
Viral envelope is present
Where does HSV 1 and 2 replicate
IN the nucleus
What dituingishing feature of HSV 1 and 2 look like during an infection
Cowdry bodies, which are intranuclear inclusion viral bodies that look like targets
How is HSV 1 and 2 transmitted
Sexual contact, saliva, and vertical trasmission (TORCH infection)
How will HSV1 appear first during an infection
Gingivostomatitis, which are very painful ulceration of the gums
What are the clinical presentations of HSV1 normal infections
-Herpes labialis, aka cold sore ulcerations on the lip
-Sepiginous ulcers (snake like) and keratoconjunctivities in the eyes
-temporal lobe encephalitis, with hemorrhaging
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What are the charactertics of the lesion seen during a HSV1 infections
Dew drops on a rose look, which is clear vesicules on a red base
What is a typical lesion location in HSV1 and who is at a higher risk of acquiring them
Heretic whitlow, which are lesions on the fingers, and are commonly seen in dentist and others who make frequent contact with mouths
What is erythema multifrom in HSV1 infections and what are their characteristics
Target lesions on the hands and feet that move from distal to proximal (they are hypersensitivity reactions
What is the method of transmission of HSV2
Sexual contact with the genitals
What are the clinical presentations of HSV2 infections
Painful vesicular lesions with inguinal lymphadenopathy
Where does HSV1 lay dormant
Trigeminal ganglia
Where does HSV2 lay dormant
Sacral ganglia
What serious condition can HSV2 cause
Aseptic meningitis
What are the methods of diagnosis of HSV1 and 2
- Tzanc smear (looking for multinucleated giant cells)
- PCR
What is the most common cause of sporadic encephalitis
HSV1
