CMV Cytomegalovirus

Question 1

CMV is which type of virus

Answer 1

DNA

Question 2

where does CMV replicate

Answer 2

nucleus

Question 3

what family is CMV in

Answer 3

herpes virus

Question 4

where is CMV latent

Answer 4

mononuclear cells

Question 5

CMV congenital infections symptoms

Answer 5

blueberry muffin rash
jaundice and hepatosplenomegaly
sensorineural hearing loss - may occur later in life
intracranial calcifications and ventriculomegaly
mental retardation/seizures

BUT MOST ARE ASYMPTOMATIC

Question 6

what may CMV cause in utero

Answer 6

hydrops fetalis –> death

Question 7

what doess CMV cause in AIDs patients?

Answer 7

Retinitis that leads to necrosis “pizza pie retitinis”
Esophagitis -linear, deep, ulcerations
Colitis - ulcerations in walls

Question 8

what will you see in cells with CMV infection

Answer 8

owl eye inclusions

Question 9

treatment of CMV?

Answer 9

gancyclovir

phoscarnate (when virus has UL97 gene mutation)

Question 10

presentation of CMV in non-immuspressed?

Answer 10

CMV mononucleiosis

Question 11

How to differentiate CMV mono vs EBV mono?

Answer 11

Negative monospot test