Retroviruses-One Cane To Rule Them All Flashcards
What is the sense and nucleic acid for HIV
Positive single sense strand RNA virus
What is the state of the envelope in HIV
Viral envelope present
What does the Gag gene code for in HIV
P24, which is the capsule protein
What does the Env gene code for in HIV
Gp41 (transmembrane protein) and gp120 (outer protein)
What does the pol gene in HIV code for
Reverse transcriptase
What are the methods of transmission for HIV
- Blood transfusions, needles, sexual contact, mother to fetus (vertical transmission)
- Is a TORCH organism
Which cells in HIV are infected first, and which are infected later in the infection
Macrophages first, then CD4
Which receptors are targeted by HIV first, and which are later in infection
Targets CCR5 early, then CXCR4
What are the symptoms for the initial infection of HIV
Flu like symptoms with cervical lymphadenopathy, enlarged tonsils, fever
At which CD4 count has HIV said to progressed to AIDS
<200
What is the association between HIV and cancer
Tendency to cause B cell lymphoma, particular diffuse large B lymphoma
What is the first diagnostic tool used to screen for HIV
Elisa for antibodies
What is the confrontation test used for diagnosis of HIV
Western blot
How are neonates tested for HIV
All neonates will be positive for ELISA and Western Blot because the mother antibodies present. Therefore, we used HIV RNA or DNA amplification tests
In the HART treatment for HIV, what is the mechanism of NRTIs
Aka nucleotide reverse transcriptase inhibator. It is a nucleotide analog, which blocks the progression of the reverse transcriptase
In HART treatment for HIV, what is the NNRTIs
aka non-nucleotide reverse transcriptase inhibator, which does not insert into the chain to inhibit
In HART treatment of HIV, what is the role of a protease inhibitor
Blocks the ability of the protease to cleave the viral protein products into the final viral products
In HART treatment for HIV, what is the function of the drug miravoroc
CCR5 inhibitor
