Orthomyxovirus-Nightshift And Orthodontis

Question 1

With regards to RNA viruses, what is the location of replication

Answer 1

Cytoplasm

Question 2

With regards RNA negative stranded viruses, which enzyme is brought along

Answer 2

RNA polymerase

Question 3

With regards to RNA negative sense strand viruses, how many strands are there

Answer 3

Single stranded

Question 4

What is the sense and nucleic acid of Otrhomyxovirus

Answer 4

RNA single stranded negative virus

Question 5

What condition does Otrhomyxovirus cause

Answer 5

Influenza

Question 6

What is the location of replication for the Otrhomyxovirus

Answer 6

Nucleus and is the exception to the RNA replication in cytosol rule

Question 7

What is the status of envelope in Otrhomyxovirus

Answer 7

Viral envelope present

Question 8

What are the strains of Otrhomyxovirus that are associated with the flu

Answer 8

ABC

Question 9

How many segments are in the Otrhomyxovirus

Answer 9

8

Question 10

What does the characteristic of being a segmented virus allow

Answer 10

Antigenic variation

Question 11

What are the segmented RNA viruses

Answer 11

BOAR
B-Bunyavirus
O-Otrhomyxovirus
A-Adenovirus
R-Reovirus

Question 12

What is antigenic drift with regards to viruses

Answer 12

Point mutations in viral genome

Question 13

What is antigenic shift

Answer 13

Segments are shared to form a new species

Question 14

What component of the viral genome is prone to the changes

Answer 14

HA (hemagglutinin) and NA (neuraminidase)

Question 15

What is the change usually seen in the epidemic/seasonal flu

Answer 15

Antigenic drift in HA and Na

Question 16

What are the changes usually seen in pandemics/serious flus

Answer 16

Antigenic shift

Question 17

Strain A of the Otrhomyxovirus is associated with which changes

Answer 17

Drift and shift

Question 18

Strain B of Otrhomyxovirus is associated with which changes

Answer 18

Drift only (only causes epidemics)

Question 19

How does the Otrhomyxovirus cause disease initially

Answer 19

Hemagglutanin (HA) binds to Salic acid in the membranes of the upper respiratory, causing RBCs to clump there

Question 20

What is the function of hemagglutinin in Otrhomyxovirus

Answer 20

Allows attachment to respiratory airways

Question 21

What is the function of M2 protein in Otrhomyxovirus

Answer 21

Allows the uncoating of virus by changing the pH and allowing NA to work

Question 22

What is the function of NA (neurominadase) in viral replication

Answer 22

Cleaves cells to allow for the release of the replicated viruses

Question 23

What part of the viral capsule allows for the tropism of the virus

Answer 23

HA decides the tropism by which cells it can attach to

Question 24

What is the drugs used to inhibit the M2 proteins

Answer 24

Amantadine

Rimantadine

Question 25

What is the mechanism of action for the Tamiflu aka oseltamivir/anamivir

Answer 25

inhibits NA and the release of the newly replicated viruses

Question 26

What is the method of transmission for the Otrhomyxovirus

Answer 26

Respiratory droplets

Question 27

What is the usual complication that leads to death with Otrhomyxovirus

Answer 27

Secondary infection with Staph Aeurus causing pneumonea

Question 28

What is Reye’s syndrome and waht causes it

Answer 28

Administration of aspirin during a viral infection. Causes encephalitis and hepatomegaly due to the uncoupling of mitochondria there

Question 29

What serious but rare condition is associated with Otrhomyxovirus

Answer 29

Guillen Barre Syndrome

Question 30

What would be the findin in the CSF during Guillen barre

Answer 30

Albunocytological disassociation (high protein and low WBC in CSF)