Bordatella Pertussis-Board And Care Flashcards
What is the method of transmission for Bordetella Pertussis
Respiratory droplets
What is the virulence factor for Bordetella Pertussis
Pili names filamentous hemagglutinin
How does Bordetella Pertussis infect the host
Pili aka filamentous hemagglutanin binds to the respiratory tract (although it is not invasive)
What are the three toxins produced by Bordetella Pertussis
- Pertussis toxin
- Edema factor (EF toxin)
- Tracheal toxin
Which organism is the EF toxin in Bordetella Pertussis similar to
Bacillis anthracis
What is the mechanism of action for the Pertusis toxin
1-Ribosylates Gi and disables it (normally an inhibitory protein)
2-Leads to rise in cAMP
3-ADP disables cytokine receptors
What is expected as a result of Bordetella Pertussis toxin
Disabled cytokine receptors, so unable to recruit lymphocytes. This leads to excess lymphocytes in the blood, aka lymphocytosis
What is the mechanism of action for the Bordetella Pertussis produced EF toxin
Aka edema factor toxin, which increases cAMP and leaking of fluid from vessels
What is the mechanism of action of the tracheal toxin produced by Bordetella Pertussis
Damages the ciliated cells of the tracheal epithelium
What are the characteristics of the catarrhal phase of infection by Bordetella Pertussis
Most infectious stage, most contagious, limited symptoms
What are the characteristics of the paroxysmal phase of Bordetella Pertussis infection
Whooping cough
What are the characteristics of the convalescence stage of Bordetella Pertussis infection
-last three months, aka 100 day cough, very susceptible to secondary infections
What is the treatment from Bordetella Pertussis
Macrolides
What is the charactertics of the Bordetella Pertussis vaccine
Acellular vaccine (purified antigens) with the DTaP group
What is the result of Gram stain with Bordetella Pertussis
Gram negative
What is the characteristic of motility with Bordetella Pertussis
Nonmotile
What is the oxygen susceptibility of Bordetella Pertussis
Aerobic
