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GI - 2 > Surface, PGE1, Bismuth Compounds for PUD and GERD (anti-ulcer) > Flashcards

Surface, PGE1, Bismuth Compounds for PUD and GERD (anti-ulcer) Flashcards

1
Q

What is the Surface Acting Agent?

A

Sucralfate

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2
Q

What is the Surface Acting Agent?

A

Sucralfate

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3
Q

Sucralfate is a?

A

Surface Acting Agent

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4
Q

What does Sucralfate undergo to exert its MOA?

A

Cross-linking from interaction with stomach acid to create a sticky polymer

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5
Q

Sucralfate becomes a sticky polymer after cross-linking due to interaction with stomach acid. What does this do?

A

Adheres to epithelial cells around the ulcer’s crater

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6
Q

Sucralfate becomes a sticky polymer after cross-linking due to interaction with stomach acid. What does this do?

A

Adheres to epithelial cells around the ulcer’s crater

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7
Q

MOA for Sucralfate (surface acting agent)?

A

Adheres to epithelial cells around the ulcer’s crater

==> Prevents acid access to ulcer

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8
Q

What does Sucralfate prevent from accessing the ulcer?

A

Acid

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9
Q

What else can Sucralfate stimulate?

A

Prostaglandins, mucous and epidermal growth factor production

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10
Q

What is Sucralfate indicated for?

A

DU

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11
Q

Drug indicated to treat DU?

A

Sucralfate

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12
Q

Adverse effect of Sucralfate?

A

Constipation

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13
Q

What drug can cause Constipation?

A

Sucralfate

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14
Q

Does Sucralfate have drug interactions?

A

Possible

= Take it 2 hours after other medications

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15
Q

Relative Contraindications for Sucralfate?

A

Severe Renal Failure

= Aluminum should be avoided

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16
Q

What in Sucralfate should be avoided for Renal Failure patients?

A

Aluminum

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17
Q

What is a PGE1 Analog?

A

Misoprostol

18
Q

What is a PGE1 Analog?

A

Misoprostol

19
Q

Misoprostol is a?

A

PGE1 Analog

20
Q

MOA for Misoprostol (PGE1 Analog)?

A

Provides protective prostaglandin actions and

Inhibits acid release from parietal cells

21
Q

What drug class provides prostaglandin actions and inhibits acid release from parietal cells?

A

Misoprostol (PGE1 Analogs)

22
Q

Generally, Misoprostol provides cytoprotection by?

A

Increasing mucosal defenses

23
Q

How does Misoprostol provide cytoprotection (mucosal defenses)?

A

Increases bicarbonate and mucous and mucosal blood flow

24
Q

PGE1 Analog (Misoprostol) is indicated for?

A

Prevention of NSAID-Induced Gastric Ulceration

prophylaxis

25
Q

What drug is used for prevention of NSAID-induced Gastric Ulceration?

A

Misoprostol

26
Q

Off label uses for Misoprostol?

A

OBGYN - pregnancy induction

27
Q

Common adverse effects of PGE1 Analogs?

A

Primarily GI-related

Some CNS-related

28
Q

Contraindications for PGE1 Analog (Misoprostol)?

A

Pregnancy

IBD

29
Q

What is a Bismuth Compound?

A

Bismuth Subsalicylate

30
Q

What is a Bismuth Compound?

A

Bismuth Subsalicylate

31
Q

MOAs for Bismuth Subsalicylate?

A

Anti-diarreal

Antimicrobial

32
Q

List the ways that Bismuth Subsalicylate is an antimicrobial and anti-diarrheal

A

(-) microbial attachment to mucosa
Inactivates enterotoxins
Disrupts bacterial cell wall

33
Q

List the ways that Bismuth Subsalicylate is an antimicrobial and anti-diarrheal

A

(-) microbial attachment to mucosa
Inactivates enterotoxins
Disrupts bacterial cell wall

34
Q

Adverse effects of Bismuth Subsalicylate?

A

Constipation

Black/dark regularly formed stools

35
Q

Adverse effects of Bismuth Subsalicylate?

A

Constipation

Black/dark regularly formed stools

36
Q

Does Bismuth Subsalicylate have drug-drug interactions?

A

Possible

= Take 2 hours after other medications

37
Q

3 relative contraindications for Bismuth Subsalicylate?

A

Antiplatelets
Anticoagulatants
Severe renal failure

38
Q

3 relative contraindications for Bismuth Subsalicylate?

A

Antiplatelets
Anticoagulation
Severe renal failure

39
Q

2 Absolute contraindications for Bismuth Subsalicylate?

A

GI bleeding

Salicylate Hypersensivity

40
Q

2 Absolute contraindications for Bismuth Subsalicylate?

A

GI bleeding

Salicylate Hypersensitivity

GI - 2 (61 decks)

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